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Mapping of thec-sis oncogene on human chromosome 22 with respect to the breakpoint associated with chronic myeloid leukaemia

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Bioscience Reports

Abstract

Chronic myeloid leukaemia (CML) cells are often characterized by the presence of a small chromosome 22, in which most of the q arm has been translocated to chromosome 9. Using cell hybrids containing different parts of chromosome 22 I have mapped thec-sis oncogene, which is known to be situated on chromosome 22, to a region distal to the CML breakpoint (22q112) and proximal to 22q13. This demonstrates thatc-sis is translocated to chromosome 9 in CML cells.

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Authors and Affiliations

  1. Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, G61 1BD, Glasgow, U.K.

    Malcolm H. Goyns

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  1. Malcolm H. Goyns
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Goyns, M.H. Mapping of thec-sis oncogene on human chromosome 22 with respect to the breakpoint associated with chronic myeloid leukaemia. Biosci Rep 3, 1107–1111 (1983). https://doi.org/10.1007/BF01120203

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  • DOI: https://doi.org/10.1007/BF01120203

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