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Effects of dexamethasone on carnitine metabolism in liver and extrahepatic tissues

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Bioscience Reports

Abstract

The in vivo effects of dexamethasone administration on liver and extrahepatic tissue carnitine concentrations were assessed in 48-h-starved rats. In heart and kidney, but not in liver, dexamethasone significantly increased total carnitine concentration. Acute (2.5 h) treatment with 2-tetradecylglycidate (TDG), a specific inhibitor of carnitine palmitoyl transferase 1, not only increased total hepatic carnitine concentrations, but also permitted an effect of dexamethasone (a further increase in hepatic carnitine concentration). The results are discussed in terms of acute (substrate-mediated) and chronic (hormonal) control of carnitine turnover.

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Authors and Affiliations

  1. Surgical Unit, The London Hospital, Whitechapel, E1 1BB, London, UK

    Timothy J. French & Anthony W. Good

  2. Department of Biochemistry, Charing Cross and Westminster Medical School, Fulham Palace Road, Hammersmith, W6 8RF, London, UK

    T. Norman Palmer

  3. Department of Chemical Pathology, London Hospital Medical College, Turner Street, E1 2AD, London, UK

    Mary C. Sugden

Authors
  1. Timothy J. French
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  2. Anthony W. Good
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  3. T. Norman Palmer
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  4. Mary C. Sugden
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French, T.J., Good, A.W., Palmer, T.N. et al. Effects of dexamethasone on carnitine metabolism in liver and extrahepatic tissues. Biosci Rep 5, 729–734 (1985). https://doi.org/10.1007/BF01119870

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  • DOI: https://doi.org/10.1007/BF01119870

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