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Effect of ruthenium red on the Ca2+ and Sr2+ efflux from rat liver mitochondria: Influence of nupercaine

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Bioscience Reports

Abstract

The rate of ruthenium-red-induced Ca2+ efflux depends on the time that the calcium interacts with the mitochondria prior to the addition of the inhibitor. This time-dependency is abolished in the presence of nupercaine; it does not occur in the case of Sr2+ efflux from mitochondria in which the endogenous Ca2+ has been substituted by strontium (strontium-treated mitochondria, STM). Ruthenium red inhibits the respiratory-inhibitor- or uncoupler-induced Sr2+ efflux from STM, but not the Ca2+ efilux from standard mitochondria. The influence of the calcium-induced mitochondrial damage upon the effect of ruthenium red is discussed.

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Authors and Affiliations

  1. Departamento de Bioquìmica Experimental, Clínica Puerta de Hierro, National Center of Medical Research, San Martín de Porres 4, 35, Madrid, Spain

    Luis Pezzi

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  1. Luis Pezzi
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Pezzi, L. Effect of ruthenium red on the Ca2+ and Sr2+ efflux from rat liver mitochondria: Influence of nupercaine. Biosci Rep 4, 231–237 (1984). https://doi.org/10.1007/BF01119658

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  • DOI: https://doi.org/10.1007/BF01119658

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