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Inhibition by dicyclohexylcarbodiimide of ATP synthesis in isolated rat hepatocytes

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Bioscience Reports

Abstract

Dicyclohexylcarbodiimide (DCCD) inhibits, by 50%, ATP synthesis in isolated hepatocytes. This inhibition is associated with DCCD-binding to a proteolipid fraction present in submitochondrial particles.

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Author notes

  1. S. Emami

    Present address: Hopital Saint-Antoine, INSERM U.55, 184 rue du Faubourg Saint-Antoine, 75571, Paris Cedex 12, France

  2. D. R. Sanadi

    Present address: Department of Cell Physiology, Boston Biomedical Research Institute, 20 Stanford Street, 02114, Boston, Massachusetts, USA

Authors and Affiliations

  1. Biological Laboratory, University of Kent, CT2 7NJ, Canterbury, Kent, UK

    S. Emami, A. Lodola, M. Partis & D. R. Sanadi

Authors
  1. S. Emami
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  2. A. Lodola
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  3. M. Partis
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  4. D. R. Sanadi
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Emami, S., Lodola, A., Partis, M. et al. Inhibition by dicyclohexylcarbodiimide of ATP synthesis in isolated rat hepatocytes. Biosci Rep 4, 189–194 (1984). https://doi.org/10.1007/BF01119653

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  • DOI: https://doi.org/10.1007/BF01119653

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