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Isoproterenol induces a ribosomal modification in the heart and the skeletal muscle of hamsters

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Bioscience Reports

Abstract

The protein synthesis activity of heart, skeletal muscle and liver polysomes from isoprotenerol-treated and control hamsters has been compared in an in vitro non-inititating translation system. Heart and skeletal muscle polysomes from treated hamsters were less active than controls and required a higher magnesium concentration for optimal protein synthesis. These results suggest that there is a conformational modification in heart and skeletal muscle ribosomes from isoprotenerol-treated hamsters. No such change was observed with ribosomes from the liver of isoproterenol-treated hamsters.

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References

  1. Deshaies Y, Willemot J & Leblanc J (1981) Can. J. Physiol. Pharmacol.59, 113–121.

    PubMed  Google Scholar 

  2. Taylor PB & Tang Q (1984) Can. J. Physiol. Pharmacol.62, 384–389.

    PubMed  Google Scholar 

  3. Zak R & Rabinowitz M (1979) Ann. Rev. Physiol.41, 539–552.

    Google Scholar 

  4. Meerson FS, Iavich MP & Leerman MI (1974) Circulation Res.34/35 Suppl. III, 43–49.

    Google Scholar 

  5. Hjalmarson S & Isaksson O (1972) Acta Physiol. Scand.86, 342–352.

    PubMed  Google Scholar 

  6. Hammond GL, Wieben E & Markert CL (1979) Proc. Natl. Acad. Sci. U.S.A.76, 2455–2459.

    PubMed  Google Scholar 

  7. Jolicoeur C & Brakier-Gingras L (1983) Can. J. Biochem. Cell Biol.61, 1–7.

    PubMed  Google Scholar 

  8. Scheele G & Blackburn P (1979) Proc. Natl. Acad. Sci. U.S.A.76, 4898–4902.

    Google Scholar 

  9. Lodish HF, Housman D & Jacobsen M (1971) Biochemistry10, 2348–2356.

    PubMed  Google Scholar 

  10. Bielka H & Stahl J (1978) Intern. Rev. Biochem.18, 79–168.

    Google Scholar 

  11. Sperrazza JM & Spremulli LL (1983) Nucleic Acids Research11, 2665–2679.

    PubMed  Google Scholar 

  12. Broude NE, Kussova KS, Medvedeva NI & Budowsky EI (1983) Eur. J. Biochem.132, 139–145.

    PubMed  Google Scholar 

  13. Terao K & Ogata K (1979) J. Biochem.86, 605–617.

    PubMed  Google Scholar 

  14. Takahashi Y & Ogata K (1981) J. Biochem.90, 1549–1552.

    PubMed  Google Scholar 

  15. Chapman RA (1983) Am. J. Physiol.245, H535-H552.

    PubMed  Google Scholar 

  16. Sperelakis N (1984) Am. Heart J.107, 347–357.

    PubMed  Google Scholar 

  17. Traugh JA (1981) in: Biochemical Actions of Hormones (Litwack G, ed), vol 3, pp 167–208, Academic Press, New York.

    Google Scholar 

  18. Kisilevsky R, Treloar MA & Weiler L (1984) J. Biol. Chem.259, 1351–1356.

    PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Département de Biochimie, Université de Montréal, H3C 3J7, Montréal, Québec, Canada

    Josette Noël & Léa Brakier-Gingras

Authors
  1. Josette Noël
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  2. Léa Brakier-Gingras
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Noël, J., Brakier-Gingras, L. Isoproterenol induces a ribosomal modification in the heart and the skeletal muscle of hamsters. Biosci Rep 5, 13–19 (1985). https://doi.org/10.1007/BF01117436

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  • DOI: https://doi.org/10.1007/BF01117436

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