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Evidence that calmodulin may be involved in phytohaemagglutinin-stimulated lymphocyte division

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Bioscience Reports

Abstract

Phytohaemagglutinin-stimulated and non-stimulated incorporation of [3H]thymidine into human peripheral blood lymphocytes is inhibited by the calcium antagonist PY 108–068 and by the calmodulin antagonists trifluo-perazine andN-(6-aminohexyl)-5-chloro-l-naphthalene sulphonamide (W7). It is argued that calmodulin may be involved in both non-stimulated [3H]thymidine uptake in lymphocytes and also in the lymphocyte response to phytohaemagglutinin.

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Authors and Affiliations

  1. Department of Medicine, Clinical Sciences Centre, Northern General Hospital, Herries Road, S5 7AU, Sheffield, UK

    Sheila Mac Neil & S. Tomlinson

  2. Department of Human Metabolism and Clinical Biochemistry, Sheffield University Medical School, Beech Hill Road, S10 2RX, Sheffield, UK

    S. W. Walker & B. L. Brown

Authors
  1. Sheila Mac Neil
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  2. S. W. Walker
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  3. B. L. Brown
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  4. S. Tomlinson
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Mac Neil, S., Walker, S.W., Brown, B.L. et al. Evidence that calmodulin may be involved in phytohaemagglutinin-stimulated lymphocyte division. Biosci Rep 2, 891–897 (1982). https://doi.org/10.1007/BF01114895

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  • DOI: https://doi.org/10.1007/BF01114895

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