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Copper induction of translatable metallothionein messenger RNA

  • Published:
Bioscience Reports

Abstract

Copper chloride injection of rats resulted in a 4.5- to 9-Iold increase in translatable metallothionein messenger RNA in the liver. Metallothionein in the translation products was identified on the basis of high cysteine and serine incorporation and absence of leucine incorporation as well as comigration with authentic zinc-induced rat-liver metallothionein on SDS-polyacrylamide gels.

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Authors and Affiliations

  1. Birth Defects Research Institute, Royal Children's Hospital, Flemington Road, 3052, Parkville, Australia

    J. F. B. Mercer, I. Lazdins & D. M. Danks

  2. Department of Genetics, University of Melbourne, 3052, Parkville, Australia

    T. Stevenson & J. Camakaris

Authors
  1. J. F. B. Mercer
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  2. I. Lazdins
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  3. T. Stevenson
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  4. J. Camakaris
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  5. D. M. Danks
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Mercer, J.F.B., Lazdins, I., Stevenson, T. et al. Copper induction of translatable metallothionein messenger RNA. Biosci Rep 1, 793–800 (1981). https://doi.org/10.1007/BF01114802

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  • DOI: https://doi.org/10.1007/BF01114802

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