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The biliary excretion of trypsin in rats

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Bioscience Reports

Abstract

The serum half-life of bovine [3H]acetyltrypsin was estimated to be 9 rain following intravenous administration in rats. This was maintained when six successive doses of 200 μg each were given at 1-h intervals. The enzyme was removed from the circulation after complexing with α2-macroglobulin (α2-M). The amount of3H label appearing in bile increased with each successive dose and this was associated with breakdown products (<10 000 daltons) of the α2−M/[3H] acetyltrypsin. Intact α−M/[3H] acetyltrypsin was recovered from bile but represented only 0.06% of the administered dose of active enzyme.

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Authors and Affiliations

  1. Department of Surgery, St. George's Hospital Medical School, SW17 ORE, London, UK

    David A. W. Grant & Simon C. Fleming

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  1. David A. W. Grant
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  2. Simon C. Fleming
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Grant, D.A.W., Fleming, S.C. The biliary excretion of trypsin in rats. Biosci Rep 1, 765–770 (1981). https://doi.org/10.1007/BF01114798

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  • DOI: https://doi.org/10.1007/BF01114798

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