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Efficacy of 6-amino-2-n-pentylthiobenzothiazole onTrichophyton in vitro and in vivo

  • Human And Animal Mycology
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Abstract

In vitro and in vivo antifungal activities of synthetically parepared 6-animo-2-n-pentylthiobenzothiazole (APB) againstTrichophyton strains were studied. APB inhibited the growth of 3Trichophyton strains at 65 µg/ml. 2-Mercaptobenzothiazole was not effective at 125 µg/ml and ketoconazole inhibited the growth at 20–30 µg/ml. Treatment of experimental dermatophytosis in guinea pigs using 2.5% APB cream was studied in comparison to Canesten cream (1% clotrimazole). Dermatophytosis was considerably reduced after both APB and Canesten therapies.

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Authors and Affiliations

  1. Drug Research Institute, Horná 36, 900 01, Modra

    Marta Múčková

  2. Department of Parasitology Faculty of Medicine, Comenius University, Sasinkova 4a, 811 08, Bratislava

    Milan Klobušický

  3. Institute of Chemistry, Faculty of Natural Sciences, Comenius University, Mlynská dolina Ch-2, 842 15, Bratislava, Slovak Republic

    Eva Sidóová

  4. Department of Microbiology and Virology, Faculty of Natural Sciences, Comenius University, Mlynská dolina B-2, 842 15, Bratislava, Slovak Republic

    Helena Bujdáková PhD.

Authors
  1. Helena Bujdáková PhD.
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  2. Marta Múčková
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  3. Milan Klobušický
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  4. Eva Sidóová
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Bujdáková, H., Múčková, M., Klobušický, M. et al. Efficacy of 6-amino-2-n-pentylthiobenzothiazole onTrichophyton in vitro and in vivo. Mycopathologia 130, 141–145 (1995). https://doi.org/10.1007/BF01103096

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  • DOI: https://doi.org/10.1007/BF01103096

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