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Favism-inducing toxins in broad beans (Vicia faba) examination of bean extracts for pyrimidine glucosides

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Abstract

Methods for the isolation and identification of the pyrimidine glucoside, vicine, in extracts of broad beans, are described, By thin-layer chromatography, five fluorescing or fluorescencequenching components of the extracts are identifiable. One of them, which has been isolated from the mixture, is identified as vicine, 2:4-diamino-5:6-dihydroxypyrimidine-5-(β-D-glucopyranoside).

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References

  • Abdel-Wahab, M.F. & El-Kinawi, S.A. (1959). ‘The acid soluble nucleotides ofVicia Faba’, Acta Chem. Scand.,13: 1653–1658.

    Google Scholar 

  • Abdel-Wahab, M.F. & El-Kinawi, S.A. (1960). ‘The acid soluble nucleotides ofVicia Faba II’, Acta Chem. Scand.,14: 1667–1672.

    Google Scholar 

  • Bendich, A. & Clements, G.C. (1953). ‘A revision of the structural formulation of vicine and its pyrimidine aglucone, divicine’, Biochem. Biophys. Acta,12: 462–477.

    Google Scholar 

  • Bien, S., Salemnik, G., Zamir, L. & Rosenblum, M. (1968). ‘The structure of convicine’, J. Chem. Soc. (C), p. 496–499.

  • Brown, E.G. (1962). ‘The acid-soluble nucleotides of mature pea seeds’, Biochem. J.,85: 633–640.

    Google Scholar 

  • Brown, E.G. (1963). ‘Purine & pyrimidine derivatives in mature pea seeds’, Biochem. J.,88: 498–504.

    Google Scholar 

  • Brown, E.G. (1965). ‘Changes in the free nucleotide and nucleoside pattern of pea seeds in relation to germination’, Biochem. J.,95: 509–514.

    Google Scholar 

  • Brown, E.G. & Roberts, F.M. (1972). ‘Formation of vicine & convicine by Vicia faba’, Phytochem.,11: 3203–3206.

    Google Scholar 

  • Gale, M. To be published, 1976.

  • Hardin, J.W. & Arena, J.M. (1969).Human Poisoning from Native and Cultivated Plants Duke University Press, Durham, North Carolina, p. 68.

    Google Scholar 

  • Knott. J.E. (1955)Vegetable Growing, 5th ed., Lea & Fobiger, Philadelphia. Chap. 23.

  • Lin, J.Y. & Ling, K.H. (1962). ‘Studies on favism. 1. Isolation of an active principle from Fava beans (vicia faba)’, J. Formosan Med. Assoc.,61: 484–488.

    Google Scholar 

  • Mager, J., Glaser, G., Razin, A., Izak, G., Bien, S. & Noam, M. (1965) ‘Metabolic effects of pyrimidines derived from fava bean glycosides on human erythrocytes deficient in glucose-6-phosphate dehydrogenase’, Biochem. Biophys. Res. Commun., 20: 235–240.

    Google Scholar 

  • Mager, J., Razin, A. & Hershko, A. (1969). ‘Favism’, Chap. 10 inToxic Constituents of Plant Foodstuffs, edited by I.E. Liener, Academic Press, New York & London.

    Google Scholar 

  • Randerath, K. (1965). ‘Two-dimensional separation of nucleic acid bases on cellulose layers’, Nature,205: 908.

    Google Scholar 

  • Shoemaker, J.S. (1953).Vegetable Growing 2nd ed., Wiley, N.Y.P. 176.

    Google Scholar 

  • Whyte, R.O. & Trumble, H.C. (1953).Legumes in Agriculture. Plant Protection Branch, Agriculture Division, Food & Agriculture Organisation of the United Nations, Rome, Italy, p. 340.

    Google Scholar 

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Jamalian, J., Aylward, F. & Hudson, B.J.F. Favism-inducing toxins in broad beans (Vicia faba) examination of bean extracts for pyrimidine glucosides. Plant Food Hum Nutr 26, 331–339 (1976). https://doi.org/10.1007/BF01099083

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