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Bile salts and bioelectric properties of rat jejunum

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Abstract

Addition of conjugated bile salts increased transmural- and transserosal-potential, differences of sheets of rat jejunum. Removal of Cl− from buffer solutions minimized the bilesalt induced bioelectric changes. Bile-salt induced doubling of tissue resistance was not explained by an observed increase in net Cl− serosa → mucosa flux. Electrical effects were unrelated to concentration and were observed only when bile-salt solutions perfused the jejunal mucosa. The molecular events associated with bile-salt interactions with the plasma membrane affecting ion fluxes may relate to their unique effects on sterol absorption.

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Author notes

  1. Daniel S. Feldman MD & Elaine B. Feldman MD

    Present address: Department of Medicine, Medical College of Georgia, 30902, Augusta, Georgia

Authors and Affiliations

  1. Department of Medicine and Division of Neurology, State University of New York Downstate Medical Center, 11203, Brooklyn, New York

    Daniel S. Feldman MD, Shelly Rabinovitch BS & Elaine B. Feldman MD

Authors
  1. Daniel S. Feldman MD
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  2. Shelly Rabinovitch BS
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  3. Elaine B. Feldman MD
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Feldman, D.S., Rabinovitch, S. & Feldman, E.B. Bile salts and bioelectric properties of rat jejunum. Digest Dis Sci 21, 242–248 (1976). https://doi.org/10.1007/BF01095897

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