Abstract
Pyloric pressure was assayed by a manometric procedure in the basal state and after intraduodenal infusion of HCl. 13 control subjects, 11 patients with benign gastric ulcer, 8 with duodenal ulcer, and 2 with coexistent gastric and duodenal ulcers were studied. Mean resting pyloric pressure in gastric-ulcer patients (5.17±0.71) mm Hg) was significantly lower than controls (9.40±0.85 mm Hg) and did not increase after HCl perfusion into the duodenum. Mean basal pyloric pressure in duodenal-ulcer patients (11.30±1.57 mm Hg) did not differ significantly from controls and increased after intraduodenal perfusion of HCl to 15.72±2.40 mm Hg. The two patients with coexistent ulcers had manometric patterns similar to gastric-ulcer patients. Decreased pyloric-sphincter pressure in gastric-ulcer patients may be the mechanism responsible for the increased duodeno-gastric reflux observed in these patients.
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References
Capper WM: Factors in the pathogenesis of gastric ulcer. Ann R Coll Surg Eng 1:21–25, 1967
Fisher RS, Cohen S: Physiological characteristics of the human pyloric sphincter. Gastroenterology 64:67–75, 1973
Rhodes J, Barnardo DE, Phillips SF, et al: Increased reflux of bile into the stomach in patients with gastric ulcer. Gastroenterology 57:241–252, 1969
Capper WM, Airth GR, Kilby JO: A test for pyloric regurgitation. Lancet 2:261–623, 1966
Valenzuela JE, Defilippi C, Eguiguren AL, et al: Estudio manometrico del esfinter pilorico. Rev Med Chile 102:841–843, 1974
Snedecor GW, Cochran WC:Statistical methods, Fifth edition. Ames, Iowa State University Press, 1956
Mehta SJ, Kaye MD, Showalter JP: Is there a pyloric sphincter? Gastroenterology 66:746, 1974
Fisher RS, Cohen S: Pyloric sphincter dysfunction in patients with gastric ulcer. New Eng J Med 288:273–276, 1973
Grant R, Grossman MI, Wang KJ, et al: The cytolytic action of some gastrointestinal secretions and enzymes on epithelial cells of gastric and duodenal mucosa. J Cell Comp Physiol 37:137–161, 1951
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Valenzuela, J.E., Defilippi, C. Pyloric-sphincter studies in peptic-ulcer patients. Digest Dis Sci 21, 229–232 (1976). https://doi.org/10.1007/BF01095895
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DOI: https://doi.org/10.1007/BF01095895