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Effect of secretin and graded doses of CCK-PZ on pancreatic secretion in man

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Abstract

We have studied the effects of cholecystokinin-pancreozymin (CCK-PZ) from the GIH laboratory in Stockholm, Sweden, on the electrolyte and enzyme secretion of the pancreas. CCK-PZ in variable doses has been given together with a constant secretin dose of 2 clinical units per kilogram hour (CU/kg-hr). The results obtained were compared with a second group of tests where secretin alone was administered in the same dose. CCK-PZ given with the same dose of secretin that produced maximal fluid and electrolyte flow does not potentiate the total bicarbonate response but does slightly increase bicarbonate concentration. The variations observed are due to the presence of acinar and biliary factors. On the other hand, administration of CCK-PZ produces a greater maximal enzyme response than we have obtained in prior studies after injection of Boots pancreozymin or caerulein. For this reason we prefer CCK-PZ to other products in pancreatic studies.

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Authors and Affiliations

  1. Groupe de Recherche de Pathologie Digestive, Service de Gastro-Entérologie, Hôpital Purpan, Toulouse, France

    N. Vaysse MD, J. Laval, M. Duffaut MD & A. Ribet MD

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  1. N. Vaysse MD
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  2. J. Laval
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  3. M. Duffaut MD
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  4. A. Ribet MD
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Vaysse, N., Laval, J., Duffaut, M. et al. Effect of secretin and graded doses of CCK-PZ on pancreatic secretion in man. Digest Dis Sci 19, 887–894 (1974). https://doi.org/10.1007/BF01076211

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