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The chemistry of peroxovanadium compounds relevant to insulin mimesis

  • Part I: Chemistry
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Abstract

The inorganic coordination chemistry of peroxovanadium compounds relevant to insulin mimesis is reviewed. The structure and kinetic reactivity of solutions of vanadate anion, vanadyl complexes and peroxovanadate complexes are briefly compared. Peroxovanadium compounds contain an oxo group, one or two peroxo ligands (O2 2−) and an ancillary ligand which is usually bidentate. These compounds approximate a trigonal bipyramidal structure which can be divided conceptually into a polar ‘oxo’ half and a relatively non-polar organic half. This presents a number of interesting design variations which are discussed with respect to the development of a rudimentary structure-activity correlation of insulin mimetic ability.

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Abbreviations

phen:

1,10-phenanthroline

4,7-Me2phen:

4,7-dimethyl-1,10-phenanthroline

3,4,7,8-Me4phen:

3,4,7,8-tetramethyl-1,10-phenanthroline

5-CH3phen:

5-methyl-1,10-phenanthroline

5-NO2phen:

5-nitro-1,10-phenanthroline

5-NH2phen:

5-amino-1,10-phenanthroline

bipy:

2,2′-bipyridine

bipyH:

2,2′-bipyridinium

4,4′-Me2bipy:

4,4′-dimethyl-2,2′-bipyridine

bipy-4,4′-(COO)2:

2,2′-bipyridine-4,4′-dicarboxylato

pic:

pyridine-2-carboxylato

3-OHpic:

3-hydroxypyridine-2-carboxylato

3-acetpic:

3-acetatoxypyridine-2-carboxylato

m,n-pdc:

pyridine-m,n-dicarboxylato

ox:

oxalato

pzc:

pyrazine-2-carboxylato

3-NH2pzc:

3-aminopyrazine-2-carboxylato

4OH-2,6pdc:

4-hydroxy-2,6-pyridinedicarboxylato

IDA:

iminodiacetato

cit:

citrato

EDTA:

ethylenediaminetetraacetato

HEDTA:

ethylene-diaminetetraacetic acid

isoquin:

isoquinoline-2-carboxylato

quin:

quinolato

NTA:

nitrilotriacetato

glyH:

glycine

cystH:

cysteine

nicH:

nicotinic acid

Hheida:

N-(2-hydroxyethyl)iminodiacetato

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  1. Departments of Chemistry and Medicine, McGill University, H3A 2K6, Montréal, Québec, Canada

    Alan Shaver, Jesse B. Ng, David A. Hall & Barry I. Posner

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  1. Alan Shaver
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Shaver, A., Ng, J.B., Hall, D.A. et al. The chemistry of peroxovanadium compounds relevant to insulin mimesis. Mol Cell Biochem 153, 5–15 (1995). https://doi.org/10.1007/BF01075913

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