Abstract
Gastric mucosal damage in previous studies has been assessed by changes in either ionic permeability or electrical potential difference, but a relation between the two has not been shown. In the present study, bile damage to gastric mucosa was investigated in dogs with Heidenhain pouches. Measurements were made of changes in the movement of sodium and hydrogen ion across the mucosa, and of transmucosal potential difference before and after contact with bile. The relation between these two indices of mucosal damage was examined, and a relation was found between some, but not all, of the values of potential difference and ionic flux. After contact with bile, mean potential difference correlated well with both sodium and hydrogen ion fluxes. Furthermore there was a significant correlation betweenchanges in the mean potential difference andchanges in the back-diffusion of hydrogen (but not of sodium) ion after contact with bile.
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References
Code CF, Higgins JA, Moll JC, Orvis AL, Scholer JJ: The influence of acid on the gastric absorption of water, sodium and potassium. J Physiol 166:110–119, 1963
Davenport HW: Destruction of the gastric mucosal barrier by detergents and urea. Gastroenterology 54:175–181, 1968
Ivey KJ, Den Besten L, Clifton JA: Effect of bile salts on ionic movement across the human gastric mucosa. Gastroenterology 59:683–690, 1970
Black RB, Hole D, Rhodes J: Bile damage to the gastric mucosal barrier: the influence of pH and bile acid concentration. Gastroenterology 61:178–184, 1971
Geall MG, Phillips SF, Summerskill WHJ: Profile of gastric potential difference in man: effects of aspirin, alcohol, bile and endogenous acid. Gastroenterology 58:437–443, 1970
Davenport HW: The proper study. Gastroenterology 58:590–591, 1970
Smith GM: An experimental study of the relation of bile to ulceration of the mucous membrane of the stomach. J Med Res 30:147–183, 1914
Lawson HH: Effect of duodenal contents on the gastric mucosa under experimental conditions. Lancet 1:469–472, 1964
Kirk RM: Experimental gastric ulcers in the rat: the separate and combined effects of vagotomy and bile-duct implantation into the stomach. Br J Surg 57:521–524, 1970
Davenport HW, Warner HA, Code CF: Functional significance of gastric mucosal barrier to sodium. Gastroenterology 47:142–152, 1964
Geall MG, Summerskill WHJ: Electric potential difference—a neglected parameter of gut integrity and function? Gut 10:418–421, 1969
Davenport HW: Fluid produced by the gastric mucosa during damage by acetic and salicylic acid. Gastroenterology 50:487–499, 1966
Davenport HW: Gastric mucosal haemorrhage in dogs: effects of acid aspirin and alcohol. Gastroenterology 56:175–181, 1969
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This work was supported in part by a Medical Research Council Grant (G969/7/C).
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Black, R.B., Rhodes, J. & Hole, D. Measurement of bile damage to the gastric mucosa. Digest Dis Sci 18, 411–415 (1973). https://doi.org/10.1007/BF01071991
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DOI: https://doi.org/10.1007/BF01071991