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Radioselenium pancreozymin-secretin test as a clinical test for pancreatic exocrine function

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Abstract

The appearance of radioselenium in the protein fraction of duodenal aspirates has been studied after an intravenous injection of75Se-selenomethionine. The continuous flow of pancreatic juice was stimulated by pancreozymin at 120 minutes and by secretin at 140 minutes. A good distinction between normal subjects and patients with pancreatic disease was obtained by measuring75Se-radioactivity in the protein fraction of duodenal aspirates; either cumulative radioactivity during the combined 80-minute post-pancreozymin-secretin period, or maximum75Se-specific activity during the postsecretin period was used as an index. The test presented here might be a useful and sufficiently reliable method for detecting abnormal pancreatic exocrine function. This test can be performed along with the conventional pancreozymin-secretin test, serum enzyme response to pancreozymin and secretin, and pancreatic scintiscanning.

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Authors and Affiliations

  1. First Department of Medicine, Osaka University Medical School, Dojimahamadori, Fukushima-ku, Osaka, Japan

    Motoaki Shichiri MD, Nobuaki Etani MD, Michio Yoshida MD, Yutaka Harano MD, Mitsuru Hoshi MD, Yukio Shigeta MD & Hiroshi Abe MD

Authors
  1. Motoaki Shichiri MD
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  2. Nobuaki Etani MD
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  3. Michio Yoshida MD
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  4. Yutaka Harano MD
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  5. Mitsuru Hoshi MD
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  6. Yukio Shigeta MD
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  7. Hiroshi Abe MD
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Additional information

This study was supported in part by a grant from Tanabe Amino Acid Research Foundation, Osaka, Japan.

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Shichiri, M., Etani, N., Yoshida, M. et al. Radioselenium pancreozymin-secretin test as a clinical test for pancreatic exocrine function. Digest Dis Sci 20, 460–468 (1975). https://doi.org/10.1007/BF01070792

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  • DOI: https://doi.org/10.1007/BF01070792

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