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The immune response to ϕX 174 in man. II. Primary and secondary antibody production in patients with Crohn's disease

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Abstract

10 patients with Crohn's disease in various states of activity have been injected with 3.3×109 plaque-forming units of the bacteriophage ϕX 174, as a test for their capacity to produce antibodies. 9 patients had a completely normal primary and secondary antibody response. One patient had higher levels of preimmunization antibodies than have been encountered in normal subjects and developed a secondary (IgG) response to the first dose of antigen. We conclude that there is no evidence of a general disturbance of antibody-producing capacity in subjects with Crohn's disease.

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Authors and Affiliations

  1. Department of Gastroenterology, Frenchay Hospital, Bristol, England

    R. C. Bucknall MB, BS, MRCP,  J. Verrier Jones BM, BCh, FRCP & D. B. Peacock MB, ChB

  2. Departments of Medicine and Bateriology, University of Bristol, England

    R. C. Bucknall MB, BS, MRCP,  J. Verrier Jones BM, BCh, FRCP & D. B. Peacock MB, ChB

  3. Department of Medicine, Southmead Hospital, BS10 5NB, Bristol, England

    J. Verrier Jones BM, BCh, FRCP

Authors
  1. R. C. Bucknall MB, BS, MRCP
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  2. J. Verrier Jones BM, BCh, FRCP
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  3. D. B. Peacock MB, ChB
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Additional information

This work was supported by grants from the Medical Research Committee of the United Bristol Hospitals, and from the Wellcome Trust.

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Bucknall, R.C., Jones, J.V. & Peacock, D.B. The immune response to ϕX 174 in man. II. Primary and secondary antibody production in patients with Crohn's disease. Digest Dis Sci 20, 430–436 (1975). https://doi.org/10.1007/BF01070787

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  • DOI: https://doi.org/10.1007/BF01070787

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