Abstract
A recent claim that inbred sublines of the Roman high and low selection strains are not differentiated for avoidance performance casts doubt on the results of an earlier triple test-cross study using the lines. However, data from 220 litters of crosses to these lines demonstrate that the claim was certainly incorrect at the time of the earlier study, 1975–1977. The anomalous results which gave rise to the claim do not fit well with our knowledge of the genetic architecture of avoidance conditioning in rats; it is unlikely that inbreeding per se results in rapid acquisition of twoway active avoidance in Roman Low Avoidance rats.
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Hewitt, J.K., Fulker, D.W. Genotypic differentiation of Roman selection lines did not “Disappear” with inbreeding. Behav Genet 14, 571–577 (1984). https://doi.org/10.1007/BF01068127
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DOI: https://doi.org/10.1007/BF01068127