Abstract
SWR/J mice avoid sucrose octaacetate (SOA) solutions at concentrations which other inbred strains do not. This phenotypic difference has been hypothesized to result from variation at a single autosomal locus with two alleles, one dominant (Soa a, aversion) and one recessive (Soa a, blind). Data from reciprocal F1 and F2 crosses of SWR/J (taster) and C57BL/6J (nontaster) mice and from four generations of selective lineal backcrossing to the C57BL/6J strain, in two-bottle preference tests with 10−5 M SOA, were used to test this monogenic model against two polygenic models. The phenotypic ratios expected in the segregating generations according to the single-locus model were consistent with the observed ratios. The ratios expected with either two-locus model were inconsistent with those found. A strain distribution pattern, also consistent with monogenic variation, was found when a set of recombinant inbred strains (SWXL/Ty) derived from SWR/J and C57L/J (nontaster) mice was similarly tested. Outbred CFW mice (inbred substrains of which had been reported by separate laboratories to be both SOA tasters and SOA nontasters) were found to be polymorphic for SOA tasting. An allele identical by descent to that in the SWR/J strain may be segregating in this (distantly) related line.
Similar content being viewed by others
References
Bailey, D. W. (1981). Recombinant inbred strains and bilineal congenic strains. In Foster, H. L., Smith, J. D., and Fox, J. G. (eds.),The Mouse in Biomedical Research, Vol. I, Academic Press, New York, pp. 223–239.
Flaherty, L. (1981). Congenic strains. In Foster, H. L., Smith, J. D., and Fox, J. G. (eds.),The Mouse in Biomedical Research, Vol. I, Academic Press, New York, pp. 215–222.
Fuller, J. L. (1974). Single-locus control of saccharin preference in mice.J. Hered. 65:33–36.
Harder, D. B., Whitney, G., Frye, P., Smith, J. C., and Rashotte, M. E. (1984). Strain differences among mice in taste psychophysics of sucrose octaacetate.Chem. Senses 9:311–323.
Hill, B. F. (1981). The CFl mouse, history and utilization. InCharles River Digest, 20, Charles River Breeding Laboratories, Wilmington, Mass.
Klein, T. W., and DeFries, J. C. (1970). Similar polymorphism of taste sensitivity to PTC in mice and men.Nature 225:555–557.
Lush, I. E. (1981a). The genetics of tasting in mice. I. Sucrose octaacetate.Genet. Res. (Camb.) 38:93–95.
Lush, I. E. (1981b). Mouse pharmacogenetics.Symp. Zool. Soc. Lond. 47:517–546. [Berry, R. J. (ed.),Biology of the House Mouse, Academic Press, New York.]
Lush, I. E. (1982). The genetics of tasting in mice. II. Strychnine.Chem. Senses 7:93–98.
Lush, I. E. (1984). The genetics of tasting in mice. III. Quinine.Genet. Res. (Camb.) 44:151–160.
Lynch, C. J. (1969). The so-called swiss mouse.Lab. Anim. Care 19:214–220.
Shingai, T., and Beidler, L. M. (1985). Interstrain differences in bitter taste responses in mice.Chem. Senses 10:51–55.
Staats, J. (1981). Inbred and segregating inbred strains. In Foster, H. L., Small, J. D., and Fox, J. G. (eds.),The Mouse in Biomedical Research, Vol. I, Academic Press, New York, pp. 177–213.
Warren, R. P., and Lewis, R. C. (1970). Taste polymorphism in mice involving a bitter sugar derivative.Nature 227:77–78.
Whitney, G., and Harder, D. B. (1986). PTC preference among laboratory mice: Understanding of a previously “unreplicated” reportBehav. Genet. (in press).
Wysocki, C. J., and Whitney, G. (1979). Transmission genetics of a specific anosmia in mice: How and Y?.Behav. Genet. 9:486–487.
Wysocki, C. J., Whitney, G., and Tucker, D. (1977). Specific anosmia in the laboratory mouse.Behav. Genet. 7:171–188.
Author information
Authors and Affiliations
Additional information
This research was supported in part by Grant NS 15560 from the NINCDS.
Rights and permissions
About this article
Cite this article
Whitney, G., Harder, D.B. Single-locus control of sucrose octaacetate tasting among mice. Behav Genet 16, 559–574 (1986). https://doi.org/10.1007/BF01066342
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01066342