Skip to main content
SpringerLink
Log in

Role of the caudate nucleus in the development of evoked synchronized activity

  • Published:
Neurophysiology Aims and scope

Abstract

Synchronized activity (spindles, augmentation response) evoked by stimulation of thalamic nonspecific, association, and specific nuclei was investigated in chronic experiments on 11 cats before and after successive destruction of the caudate nuclei. After destruction of the caudate nuclei the duration of spindle activity in the frontal cortex and subcortical formations (thalamic nuclei, globus pallidus, putamen) was reduced to only three or four oscillations. In the subcortical nuclei its amplitude fell significantly (by 50±10%); in the cortex the decrease in amplitude was smaller and in some cases was not significant. Different changes were observed in the amplitude of the augmentation response, depending on where it was recorded. In the subcortical formations it was considerably and persistently reduced (by 50±10%); in the cortex these changes were unstable in character. Unilateral destruction of the caudate nucleus inhibited synchronized activity evoked by stimulation of the thalamic nuclei on the side of the operation only. Destruction of the basal ganglia (caudate nucleus, globus pallidus, entopeduncular nucleus, and putamen) did not prevent the appearance of synchronized activity; just as after isolated destruction of the caudate nucleus, after this operation synchronized activity was simply reduced in duration and amplitude. It is suggested that the caudate nucleus exerts an ipsilateral facilitatory influence on the nonspecific system of the thalamus during the development of evoked synchronized activity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literature cited

  1. S. M. Butkhuzi, Electrophysiological Investigation of the Functions of the Caudate Nucleus [in Russian], Metsniereba, Tbilisi (1971), 240 pp.

    Google Scholar 

  2. A. I. Gorbachevskaya, "Efferent connections of the various parts of the caudate nucleus with the thalamus in cats," Arkh. Anat. Gistol. Émbriol.,60, No. 6, 86 (1971).

    Google Scholar 

  3. H. M. Hruzdyev (G. M. Gruzdev), "Cortical bioelectrical activity in cats after unilateral destruction of the caudate nuclei," Fiziol. Zh. (Ukr.),11, No. 5, 596 (1965).

    Google Scholar 

  4. S. F. Ermolenko, "Projection of the caudal part of the head and the body of the caudate nucleus on the cerebral cortex in the cat," Arkh. Anat. Gistol. Émbriol.,61, No. 9, 24 (1971).

    Google Scholar 

  5. R. F. Makul'kin, V. V. Russev, and F. N. Serkov, "On cortical regulation of the burst electrical activity of the brain," Abstracts of Proceedings of the 11th Congress of the All-Union Physiological Society [in Russian], Vol. 2, Leningrad (1970), p. 39.

  6. L. M. Mukhametov, "Investigation of the rhythm of sleep spindles of the electroencephalogram in mammals," Author's Abstract of Candidate's Dissertation, Moscow (1967), 18 pp.

  7. S. P. Narikashvili, E. S. Moniava, and V. S. Arutyunov, "The origin of perodic fluctuations in the amplitude of cortical slow potentials," Fiziol. Zh. SSSR,51, 9 (1965).

    PubMed  Google Scholar 

  8. N. N. Oleshko, "Evoked spindle activity in the cortex and subcortical formations," Abstracts of Proceedings of the 6th All-Union Conference on Electrophysiology of the CNS, October 1–6, 1971 [in Russian], Leningrad (1971), pp. 200–201.

  9. N. N. Oleshko, V. A. Maiskii, and L. A. Savos'kina, "The efferent connections of the caudate nucleus in cats," Neirofiziologiya,7, No. 2, 165 (1975).

    Google Scholar 

  10. N. N. Oleshko and O. A. Rubasheva, "Role of the lenticular nucleus in evoked synchronized activity," Fiziol. Zh. SSSR,61, 47 (1975).

    PubMed  Google Scholar 

  11. F. N. Serkov, R. F. Makul'kin, and V. V. Russev, "Effect of divisions of the brain stem and thalamic radiation on brain electrical activity," Fiziol. Zh. SSSR,46, 408 (1960).

    PubMed  Google Scholar 

  12. V. A. Cherkes, "Physiological analysis of ascending connections of the basal ganglia," Fiziol. Zh. SSSR,69, 158 (1963).

    Google Scholar 

  13. C. Ajmone-Marsan and M. Dilworth, "Non-specific projection system of the thalamus and striate system. Electrophysiological study," Third International Congress of Electroencephalography and Clinical Neurophysiology, August 17–22, 1953, Abstracts, Electroenceph. Clin. Neurophysiol., Suppl. No. 3, 85 (1953).

  14. P. Andersen and S. A. Andersson, Physiological Basis of the Alpha Rhythm, Appleton-Century-Crofts, New York (1968), 235 pp.

    Google Scholar 

  15. F. Angeleri, G. F. Marchesi, and A. Quattrini, "Effects of chronic thalamic lesions on the electrical activity of the neocortex and on sleep," Arch. Ital. Biol.,107, 633 (1969).

    Google Scholar 

  16. E. W. Dempsey and R. S. Morison, "The electrical activity of a thalamocortical relay system," Am. J. Physiol.,138, 283 (1943).

    Google Scholar 

  17. G. Diecmann and K. Sasaki, "Recruiting responses in the cerebral cortex produced by putamen and pallidum stimulation," Exp. Brain Res.,10, 236 (1970).

    PubMed  Google Scholar 

  18. J. Hanbery and H. H. Jasper, "Independence of diffuse thalamo-cortical projection system shown by specific nuclear destruction," J. Neurophysiol.,16, 252 (1953).

    PubMed  Google Scholar 

  19. H. H. Jasper and C. Ajmone-Marsan, A Stereotaxic Atlas of the Diencephalon of the Cat, National Research Council of Canada, Ottawa (1954).

    Google Scholar 

  20. F. Schulman and J. Auer, "Caudate efferents to the thalamus," Anat. Rec.,127, 363 (1957).

    Google Scholar 

  21. T. Shimamoto and M. Verzeano, "Relations between caudate and diffusely projecting thalamic nuclei," J. Neurophysiol.,17, 278 (1954).

    PubMed  Google Scholar 

  22. N. Stoupel and C. Terzuolo, "Étude électrophysiologique des connexions et de la physiologie du noyau caudé," Acta Neurol. Psychiat. Belg.,54, 239 (1954).

    Google Scholar 

  23. M. Velasco and D. B. Lindsley, "Role of orbital cortex in regulation of thalamocortical electrical activity," Science,149, 1375 (1965).

    PubMed  Google Scholar 

  24. M. Velasco, J. E. Skinner, and D. B. Lindsley, "Blocking of electrocortical activity mediated by a thalamocortical system by lesions in the forebrain and rostral diencephalon," Electroenceph. Clin. Neurophysiol.,22. 292 (1967).

    Google Scholar 

  25. T. J. Voneida, "An experimental study of the course and destination of fibers arising in the head of the caudate nucleus in the cat and monkey," J. Comp. Neurol.,115, 75 (1960).

    PubMed  Google Scholar 

Download references

Authors
  1. N. N. Oleshko
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. K. Berezovskii
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

A. A. Bogomolets Institute of Physiology, Academy of Sciences of the Ukrainian SSR, Kiev. Translated from Neirofiziologiya, Vol. 9, No. 3, pp. 239–248, May–June, 1977.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Oleshko, N.N., Berezovskii, V.K. Role of the caudate nucleus in the development of evoked synchronized activity. Neurophysiology 9, 186–193 (1977). https://doi.org/10.1007/BF01063390

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01063390

Keywords

Search

Navigation