Abstract
The intestinal absorption of D-xylose was studied during acute poisoning of male Wistar rats receiving intragastrically potassium nitrate and sodium nitrite and small intestine perfusion with these compounds. The metabolic parameters, Na+/K+-ATPase, alkaline phosphatase, oxygen uptake, and lactic acid level, were assessed in the small intestine mucosa one hour after administration of these compounds. Exercise was demonstrated to reduce the intestinal absorption of D-xylose, to raise the level of lactic acid, and to increase the oxygen uptake by the small intestine mucosa, but caused no changes in the activity of Na+/K+-ATPase or alkaline phosphatase. Also, exercise failed to change the direction of the toxic effects of sodium nitrite but increased potassium nitrate toxicity as evidenced by reduced absorption of D-xylose from the intestine despite lack of changes of the enzymes Na+/K+-ATPase and alkaline phosphatase in the mucosa.
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References
Banwell JG (1984) Environmental contaminant effect on human intestine function. In: Schiller CM (ed) Intestinal toxicology Raven Press. NY, pp 193–208
Cammack J, Read NW, Cann PA, Greenwood B, Holgate AM (1982) Effect of prolonged exercise on the passage of a solid meal through the stomach and small intestine. Gut 23:957–966
Fordtran JS, Saltin B (1967) Gastric emptying and intestinal absorption during prolonged severe exercise. J Appl Physiol 23:331–342
Garcia-Castneirass S, White JJ, Rodriquez LD, Toro-Goyco E (1977) Inhibition of Na,K-dependent ATPase by serotonin. Mol Pharmacol 26:589–594
Gershon MD, Erde SM (1981) The nervous system of the gut. Gastroenterology 80:1571–1594
Grudziński I, Szymański A (1989) Assessment of D/+/-xylose absorption in acute and subacute poisoning with potassium nitrate and sodium nitrite. Lek Wojsk 65:433–438
Grudziński I (1990a) Selected hygienic-feeding problems of nitrates and nitrites. Lek Wojsk 66:88–90
—, — (1990b) Nitrosoamines, nitrosoamides—carcinogens in the food. Lek Wojsk 66:225–228
Jasińska-Zubelewicz EJ, Kirschner H (1976) Intestinal absorption in elderly woman. Pol Tyg Lek 31:921–923
—, — (1980) Evaluation of intestinal D-xylose absorption during graded exercise under different temperature conditions. Med Prac 31:269–275
Jervis HE, Johnson FR, Sheff MF, Smyth DH (1956) The effect of phlorizin on intestinal absorption and intestinal phosphatase. J Physiol 134:675–688
Johnson SM, Katayama Y, North RA (1980) Multiple actions of 5-hydroxytryptamine on myenteric neurons of the guinea pig ileum. J Physiol 304:459–467
Kesik M (1967) The influence of certain sodium and magnesium salts on the absorption of glucose in the small intestine of the ratin vivo. Studia Soc Sci Tor 3:1–42
Kirschner H, Jasińska-Zubelewicz EJ (1980) Changes in intestinal absorption of D-xylose as affected by occupational workload in hot environment. Med Prac 31:261–268
Klassen WH, Lanzkowski P (1964) Determination of D(+)-xylose in blood. Clin Chim Acta 9:183–185
Kobold EE, Thal AP (1963) Quantitation and identification of vasoactive substances liberated during various types of experimental intestinal ischaemia. Surg Gynec Obstet 117:315–323
Lowry GH, Rosenbrough NJ, Farr AL, Randal RJ (1952) Protein measurements with the Folin phenol reagent. J Biol Chem 193:265–275
Putney JW, Askari A (1978) Modification of membrane function by drugs. In: TE Andreoli, JF Roffman, DD Fanestil (eds) Physiology of membrane disorders Plenum Medical Book Co, NY, pp 417–438
Ramsbottom N, Hunt JN (1974) Effect of exercise on gastric emptying and gastric secretion. Digestion 10:1–12
Reddy BS (1972) Studies on the mechanism of calcium and magnesium absorption in germ free rats. Arch Biochem Biophys 149:15–21
Roe JH, Rice EW (1948) A photometric method for the determination of free pentoses in animal tissues. J Biol Chem 173:507–512
Roediger WE, Radcliffe BC, Deakin EJ, Nance SH (1986) Specific metabolic effect of sodium nitrite on fat metabolism by mucosal cells of the colon. Dig Dis Sci 31:535–539
Roediger WE, Radcliffe BC (1988) Role of nitrite and nitrate as a redox couple in the rat colon. Gastroenterology 94:915–922
Sheff MF, Smyth DH (1955) An apparatus for the studyin vivo intestinal absorption in the rat. J Physiol 128:67–71
Ström G (1949) Influence of anoxia on lactate utilization in man after prolonged muscular work. Acta Physiol Scand 17:440–451
Szymanski A (1978) Influence of intensive exercise on intestinal absorption of vitamin C in interaction with glucose and amino acids. Monografie AWF Poznan 115:151–162
—, — (1980) Intestinal absorption of thiamine and vitamin C at rats subjected to vibration and increased temperature. Roczn WIHE 19:81–94
—, — (1988) New aspects in the study of the mechanism of intestinal absorption of thiamine in rats. Acta Physiol Pol 39:450–459
Umbreit WW, Burris RH, Stanffer JF (1959) Manometric techniques. Burgess Publishing Co, USA
Williams JH, Mager M, Jacobson ED (1964) Relationship of mesenteric blood flow to intestinal absorption of carbohydrates. J Lab Clin Med 63:853–861
Wiśniewski K, Moniuszko-Jakoniuk J, Buczko W, Braszko J (1974) The effect of post-exercise activation of fibrynolytic and kininforming enzymes on the action and tissue distribution of certain drugs. Acta Physiol Pol 25:483–491
Wood JD, Mayer CJ (1979) Serotonergic activation of tonic-type enteric neurons in guinea pig small bowel. J Neurophysiol 42:582–593
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Grudziński, I., Szymański, A. & Chomiczewski, K. The effect of exercise associated with acute poisoning with potassium nitrate and sodium nitrite on the processes of intestinal absorption of D-Xyplose in rats. Arch. Environ. Contam. Toxicol. 21, 468–474 (1991). https://doi.org/10.1007/BF01060372
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DOI: https://doi.org/10.1007/BF01060372