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Concentration profile for the dissolution of drug tablets undergoing simultaneous degradation

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Abstract

An empirical approach to the concentration-time history of a dissolving drug has resulted in a cube-root equation in which the characteristic constant of the equation embodies the important physical variables of the system. This expression has been used to study the dissolution of a drug that degrades simultaneously in the test solution. An alternative representation of the dissolution process is first-order kinetics. These two approaches are compared by fitting the experimental data of the dissolution of digoxin and melphalan tablets in various media, and a new method for the proper analysis of data for the dissolution of tablets that simultaneously degrade in the test solution is presented.

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Authors and Affiliations

  1. Department of Chemical Engineering, University of Arizona, 85721, Tucson, Az

    H. -S. George Chen & Joseph F. Gross

  2. Section of Hematology and Oncology, Department of Internal Medicine, College of Medicine, University of Arizona, 85724, Tucson, Az

    H. -S. George Chen, Sai Y. Chang & Thomas L. Evans

Authors
  1. H. -S. George Chen
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  2. Sai Y. Chang
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  3. Thomas L. Evans
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  4. Joseph F. Gross
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Additional information

This work was supported by Grant CA-17094 from the National Cancer Institute, and a donation by Burroughs Wellcome Company, Research Triangle Park, North Carolina.

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Chen, H.S.G., Chang, S.Y., Evans, T.L. et al. Concentration profile for the dissolution of drug tablets undergoing simultaneous degradation. Journal of Pharmacokinetics and Biopharmaceutics 8, 621–631 (1980). https://doi.org/10.1007/BF01060057

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  • DOI: https://doi.org/10.1007/BF01060057

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