The release kinetics of afobazole from a new solid dosage form of prolonged-release film-coated tablets was studied in vitro. The conditions of the dissolution test were experimentally determined with the use of the basket apparatus type I and phosphate buffer solution pH 6.8 (Eur. Ph.) as the dissolution medium. The specification release limits were ≤25% after 1 h, 45 – 60% after 6 h, and ≥80% after 24 h of the nominal afobazole content in the tablets. The release kinetics of afobazole from the prolonged-release tablets were evaluated using the first-order, Higuchi, and Korsmeyer(Peppas mathematical models. The release mechanism of the active ingredient from the matrix could be characterized as anomalous diffusion according to the Korsmeyer(Pappas model.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 57, No. 1, pp. 59 – 64, January, 2023.
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Sergeeva, M.S., Grushevskaya, L.N., Gaevaya, L.M. et al. Release Kinetics Study and Development of Conditions for Dissolution Test of Afobazole new Prolonged-Release Solid Dosage Form. Pharm Chem J 57, 123–128 (2023). https://doi.org/10.1007/s11094-023-02859-4
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DOI: https://doi.org/10.1007/s11094-023-02859-4