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Gastrointestinal absorption of quinidine from some solutions and commercial tablets

  • Theodor W. Guentert
  • Robert A. Upton
  • Nicholas H. G. Holford
  • Alan Bostrom
  • Sidney Riegelman
Article

Abstract

The gastrointestinal absorption of quinidine from three commercially available tablet products has been compared to that from a quinidine sulfate solution previously found to have 70% of the systematic availability of an intravenous dose. Quinidine gluconate solution was included in the study to compare the absorption characteristics of the two quinidine salts. The tablets were given in a counterbalanced sequence preceded by one quinidine solution and followed by the other in a crossover design. The three tablets proved to be equivalent to one another with respect to extent and rate of absorption. The absorption properties of the two solutions were indistinguishable. The tablets were equivalent to the solutions in extent but not in rate of absorption.

Key words

quinidine bioavailability absorption solutions rapidiy releasing tablets humans 

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Copyright information

© Plenum Publishing Corporation 1980

Authors and Affiliations

  • Theodor W. Guentert
    • 1
  • Robert A. Upton
    • 1
  • Nicholas H. G. Holford
    • 2
  • Alan Bostrom
    • 3
  • Sidney Riegelman
    • 1
  1. 1.Department of Pharmacy, School of PharmacyUniversity of CaliforniaSan Francisco
  2. 2.Division of Clinical Pharmacology, Department of Medicine, School of MedicineUniversity of CaliforniaSan Francisco
  3. 3.Scientific Computing ServicesUniversity of CaliforniaSan Francisco

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