Abstract
The effect of microelectrophoresis of glutamate on spontaneous activity of sensomotor cortical neurons located 80–250 µ from the point of application of glutamate was studied in cats anesthetized with pentobarbital. If glutamate was applied at distances of under 100 µ from the neurons the predominant response was one of excitation, evidently due to the direct action of the excitatory mediator. With more distant application inhibition of spontaneous activity predominated: at distances from 100 to 200 µ it was observed in 57%, and between 200 and 250 µ, in 70% of cases. Application of picrotoxin close to the neuron weakened inhibition induced by microelectrophoresis of glutamate through a neighboring microelectrode.
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Literature cited
A. A. Aleksandrov and N. A. Shcheinikov, "Action of picrotoxin on receptive fields of sensomotor cortical neurons in the cat," Fiziol. Zh. SSSR,67, No. 3, 357 (1981).
A. S. Batuev, T. A. Bragina, A. A. Aleksandrov, and G. P. Dem'yanenko, "A multidisciplinary approach to the study of inhibition in the cerebral cortex," Fiziol. Zh. SSSR,65, No. 8, 1122 (1979).
A. S. Batuev, T. A. Bragina, and A. A. Aleksandrov, "Structural and functional basis of intracortical inhibition," in: Formation and Inhibition of Conditioned Reflexes [in Russian], Nauka, Moscow (1980), pp. 99–106.
B. P. Mochenkov and A. A. Aleksandrov, "A transistorized multiple injector for micro-iontophoresis," Fiziol. Zh. SSSR,63, No. 3, 466 (1977).
P. Andersen and I. A. Langmoen, "Intracellular studies on transmitter effects on neurones in isolated brain slices," Quart. Rev. Biophys.,13, No. 1, 1 (1980).
H. Asanuma and I. Rosen, "Spread of mono- and polysynaptic connections within cat's motor cortex," Exp. Brain Res.,16, No. 5, 507 (1973).
T. I. Biscoe and D. R. Curtis, "Strychnine and cortical inhibition," Nature,214, 914 (1967).
T. Chujo, I. Yamada, and C. Yamamoto, "Sensitivity of Purkinje cell dendrites to glutamic acid," Exp. Brain Res.,23, No. 3, 293 (1975).
D. R. Curtis and D. Felix, "The effect of bicuculline upon synaptic inhibition in the cerebral and cerebellar cortices of the cat," Brain Res.,34, No. 2, 301 (1971).
A. Herz, W. Zieglgänsberger, and G. Färber, "Microelectrophoretic studies concerning the spread of glutamic acid and GABA in brain tissue," Exp. Brain Res.,9, No. 3, 221 (1969).
R. Hess, K. Negishi, and O. Creutzfeldt, "The horizontal spread of intracortical inhibition in the visual cortex," Exp. Brain Res.,22, No. 4, 415 (1975).
R. Hess, D. Ostendorf, and D. Sanides, "Neural connections in the visual cortex as revealed by intracortical stimulation," Exp. Brain Res.,23, No. 1, Suppl. 384 (1976).
L. P. Renaud and J. S. Kelly, "Identification of possible inhibitory neurons in the pericruciate cortex of the cat," Brian Res.,79, No. 1, 9 (1974).
W. Zieglgänsberger and J. Champagnat, "Cat spinal motoneurones exhibit topographic sensitivity to glutamate and glycine," Brain Res.,160, No. 1, 95 (1979).
Additional information
A. A. Ukhtomskii Physiological Research Institute, A. A. Zhdanov Leningrad State University. Translated from Neirofiziologiya, Vol. 14, No. 4, pp. 347–352, July–August, 1982.
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Aleksandrov, A.A., Dutova, E.A. & Malova, I.V. Effect of intracortical chemical stimulation on spontaneous sensomotor cortical unit activity in cats. Neurophysiology 14, 257–261 (1982). https://doi.org/10.1007/BF01058732
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DOI: https://doi.org/10.1007/BF01058732