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Clinical application of18F-FUdR in glioma patients — PET study of nucleic acid metabolism

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Summary

Positron emission tomography was used to investigate the metabolism of nucleic acids by18F-fluoro-2′-deoxyuridine (18F-FUdR) in 22 patients with gliomas. Sixteen cases of high grade glioma clearly demonstrated a region of high activity with a differential absorption rate (DAR) of 0.64 ± 0.34. Six cases of low grade glioma failed to reveal a positive image of the tumor and the DAR in tumor was 0.21 ± 0.042 (p < 0.01). This PET-18F-FUdR study succeeded in differentiating high and low grade gliomas from the view point of nucleic acid metabolism.

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Authors and Affiliations

  1. Department of Neurosurgery, Tohoku University School of Medicine, Japan

    Motonobu Kameyama, Yuji Tsurumi, Jun Itoh, Kiyotaka Sato, Ryuichi Katakura & Takashi Yoshimoto

  2. Division of Nuclear Medicine, Cyclotron RI Center, Tohoku University, Japan

    Jun Hatazawa & Masatoshi Ito

  3. Division of Radiopharmaceutical Chemistry, Cyclotron RI Center, Tohoku University, Japan

    Kiichi Ishiwata & Tatsuo Ido

Authors
  1. Motonobu Kameyama
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  2. Kiichi Ishiwata
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  3. Yuji Tsurumi
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  4. Jun Itoh
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  5. Kiyotaka Sato
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  6. Ryuichi Katakura
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  7. Takashi Yoshimoto
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  8. Jun Hatazawa
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  10. Tatsuo Ido
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Kameyama, M., Ishiwata, K., Tsurumi, Y. et al. Clinical application of18F-FUdR in glioma patients — PET study of nucleic acid metabolism. J Neuro-Oncol 23, 53–61 (1995). https://doi.org/10.1007/BF01058459

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