Abstract
We have examined the capillary permeability within and adjacent to experimental rat gliomas, and the effect of intracarotid administration of cisplatin in this model. Permeability to14C-sucrose was 25-fold and six-fold higher within the brain tumor and in the tumor periphery and adjacent tissue respectively than in the normal cortex. Intracarotid administration of cisplatin resulted in ten-fold increase in experimental gliomas and also a significant increase in the tumor periphery and adjacent tissue, when compared to the intravenous route. Intracarotid administration of cisplatin to rat did not cause acute vascular damage in either the brain or brain tumor at the dosage used.
Similar content being viewed by others
References
Mahaley MS, Hipp SW, Dropcho EJ, Bertsch L, Cush S, Tirey T, Gillespie Y: Intracarotid cisplatin chemotherapy for recurrent gliomas. J Neurosurg 70: 371–378, 1989
Seiki Y, Shibata I, Terao H, Kudo M, Noguchi T: Pharmacokinetic study of selective continuous internal carotid CDDP infusion in malignant brain tumors. Neurol Med Chir (Tokyo) 31: 695–701, 1991
Kapp JP, Sanford RA: Neurological deficit after carotid infusion of cisplatin and 1,3-Bis-(2-chloroethyl)-1-nitrosourea (BCNU) for malignant glioma: An analysis of risk factors. Neurosurgery 19: 779–783, 1986
Loew F, Papavero L: The intraarterial route of drug delivery in the chemotherapy of malignant brain tumors. In: Symon L, Brihaye J, Cohadon F, Guidetti B, Loew F, Miller JD, Nornes H, Pasztor E, Pertuiset B, Yasargil MG (eds) Advances and Technical Standards in Neurosurgery, Vol 16, Springer-Verlag, Wien, 51–79, 1988
Newton HB, Page MA, Junck L, Greenberg HS: Intra-arterial cisplatin for the treatment of malignant gliomas. J Neuro-oncol 7: 39–45, 1989
Neuwelt EA, Glasberg M, Frenkel E, Barnett P: Neurotoxicity of chemotherapeutic agents after blood-brain barrier modification: Neuropathological studies. Ann Neurol 14: 316–324, 1983
Ohno K, Fredericks WR, Rapoport SI: Osmotic opening of the blood-brain barrier to methotrexate in the rat. Surg Neurol 12: 323–328, 1979
Ohno K, Pettigrew KD, Rapoport SI: Lower limits of cerebrovascular permeability to nonelectrolytes in the conscious rat. Am J Physiol 253: H299-H307, 1978
Hasegawa H, Ushio Y, Hayakawa T, Yamada K, Mogami H: Changes of blood-brain barrier in experimental metastatic brain tumors. J Neurosurg 59: 304–310, 1983
Yamada K, Ushio Y, Hayakawa T, Kato A, Yamada N, Mogami H: Quantitative autoradiographic measurement of blood-brain barrier permeability in the rat glioma model. J Neurosurg 57: 394–398, 1982
Neuwelt EA, Barnett PA, Frenkel EP: Chemotherapeutic agent permeability to normal brain and delivery to avian sarcoma virus-induced brain tumors in the rodent: Observations on problems of drug delivery. Neurosurgery 14: 154–160, 1984
Suzuki M, Hori K, Abe I, Saito S, Sato H: A new approach to cancer chemotherapy. Selective enhancement of tumor blood flow with angiotensin II. J Natl Cancer Inst 67: 663–669, 1981
Tsuruo T, Iida H, Tsukagoshi S, Sakurai Y: Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors. Cancer Res 42: 4730–4733, 1982
Nagahiro S, Yamamoto YL, Diksic M, Mitsuka S, Sugimoto S, Feindel W: Neurotoxicity after intracarotid 1,3-Bis(2-chloroethyl)-1-nitrosourea administration in the rat: Hemodynamic changes studied by double-tracer autoradiography. Neurosurgery 29: 19–26, 1991
Hollis PH, Zappulla RA, Spiegelman MK, Feuer EJ, Johnson J, Holland JF, Malis LI: Physiological and electrophysiological consequences of etoposide-induced blood-brain barrier disruption. Neurosurgery 18: 581–586, 1986
Anabuki K, Kohda S, Takahashi N: Cisplatin: Acute toxicity in mice and rats (in Japanese). Jpn Pharmacol Ther 10: 181–189, 1982
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ichimura, K., Ohno, K., Aoyagi, M. et al. Capillary permeability in experimental rat glioma and effects of intracarotid CDDP administration on tumor drug delivery. J Neuro-Oncol 16, 211–215 (1993). https://doi.org/10.1007/BF01057035
Issue Date:
DOI: https://doi.org/10.1007/BF01057035