Abstract
Resting membrane potential of both innervated and denervated rat diaphragm muscle fibers was investigated when the concentration of potential-producing ions was changed in the external fluid and following treatment with furosemide. It was found that equilibrium potential (\(E_{Cl^ - }\)) equalled resting potential level in innervated muscle for Cl−, but shifts to more positive values compared with resting membrane potential following section of the nerve. Furosemide retards development of post-denervation depolarization of the muscle membrane. It is deduced that trophic influences originating from the motor nerve activates the furosemide-sensitive Cl− influx system, leading to raised intracellular concentration of Cl−, a shift in (ECl) and depolarization of the muscle membrane.
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Additional information
S. V. Kurashov Medical Institute, Minsitry of Health of the RSFSR, Kazan'. Translated from Neirofiziologiya, Vol. 19, No. 6, pp. 766–771, November–December, 1987.
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Urazaev, A.K., Surovtsev, V.A., Chikin, A.V. et al. Neurotrophic control of the transmembrane Cl− pump in mammalian muscle fibers. Neurophysiology 19, 555–559 (1987). https://doi.org/10.1007/BF01056921
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DOI: https://doi.org/10.1007/BF01056921