Abstract
Prochloraz (N-propyl-N-[2-(2,4,6-trichlorophenoxy)ethyl]-1H-imidazole-1-carboxamide) is a new agricultural fungicide. When administered in the diet, it induced hepatic and intestinal cytochrome P-450 levels and monooxygenase activities from Japanese quail (Coturnix coturnix), grey partridge (Perdix perdix), chicken (Gallus gallus), and pheasant (Phasianus colchicus). After administration of a single dose to quail, prochloraz acted biphasically,i.e. inhibited, then induced aniline hydroxylase activity. In close relation with this biphasic pattern, pentobarbital sleeping time and toxicity of the insecticide parathion were modified. Administration of prochloraz at various dose levels in the diet of quail did not influence fecundity, fertility, and development of progeny.
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References
Ball WL, Sinclair JW, Crevier M, Kay K (1954) Modification of parathion's toxicity for rats by pretreatment with chlorinated hydrocarbon insecticides. Can J Biochem Physiol 32:440–445
Bartlet AL, Kirinya LM (1976) Activities of mixed-function oxidases, UDP-glucuronyl transferase and sulphate conjugation enzymes in Galliformes and Anseriformes. Quat J Exp Physiol 61:105–119
Buckpitt AR, Boyd MR (1982) Metabolic activation of 4-ipomeanol by avian tissue microsomes. Toxicol Appl Pharmacol 65:53–62
Bunyan PJ, Page JMJ (1978) Polychlorinated biphenyls. The effect of structure on the induction of quail hepatic microsomal enzymes. Toxicol Appl Pharmacol 43:507–518
Burke MD, Mayer RT (1974) Ethoxyresorufin: Direct fluorometric assay of a microsomal O-dealkylation which is preferentially inducible by 3-methylcholanthrene. Drug Metab Dispos 2:583–588
Bursian SJ, Polin D, Olson BA, Shull LR, Marks HL, Siegel HS (1983) Microsomal enzyme induction, egg production, and reproduction in three lines of Japanese quail fed polybrominated biphenyls. J Toxicol Environ Hlth 12:291–307
Chhabra RS (1979) Intestinal absorption and metabolism of xenobiotics. Environ Hlth Perspect 33:61–69
Chhabra RS, Fouts JR (1976) Biochemical properties of some microsomal xenobiotic-metabolizing enzymes in rabbit small intestine. Drug Metab Dispos 4:208–214
Conney AH (1967) Pharmacological implications of microsomal enzyme induction. Pharmacol Ther 19:317–366
Davison KL, Mollenhauer HH, Younger RL, Cox JH (1976) Mirex-induced hepatic changes in chickens, Japanese quail and rats. Arch Environ Contam Toxicol 4:469–482
DuBois KP, Kinoshita FK (1968) Influence of induction of hepatic microsomal enzymes by phenobarbital on toxicity of organic phosphate insecticides. Proc Soc Exp Biol Med 129:699–702
Estabrook RW, Werringloer J (1978) The measurement of difference spectra: Application to the cytochromes of microsomes. In: Fleischer S, Packer L (eds) Methods in Enzymology. Academic Press, New York, 52C:212–220
Estabrook RW, Werringloer J, Peterson JA (1979) The use of animal subcellular fractions to study type I metabolism of xenobiotics. In: Paulson GD, Frear DS, Marks EP (eds) Xenobiotic metabolism:in vitro methods. ACS Symposium series 97, American Chemical Society, Washington DC, pp 149–179
Goldstein JA, Linko P, Huckins JN, Stalling DL (1982) Structure-activity relationships of chlorinated benzenes as inducers of different forms of cytochrome P-450 in rat liver. Chem-Biol Interact 41:131–139
Hartree EF (1972) Determination of protein: A modification of the Lowry method that gives a linear photometric response. Anal Biochem 48:422–427
Mazel P (1971) Experiments illustrating drug metabolismin vitro. In: LaDu BN, Mandel HG, Way EL (eds) Fundamentals of drug metabolism and drug disposition. Williams and Wilkins, Baltimore, pp 546–582
Menzer RE, Best NH (1968) Effect of phenobarbital on the toxicity of several organophosphorous insecticides. Toxicol Appl Pharmacol 13:37–42
Miranda CL, Wang JL, Henderson MC, Carpenter HM, Nakaue HS, Buhler DR (1983) Differential induction of hepatic drug metabolizing enzymes in Japanese quail by 1,2,4-trichlorobenzene. Toxicology 28:75–82
Pan HP, Fouts JR (1978) Drug metabolism in birds. Drug Metab Rev 7:1–253
Prough RA, Burke MD, Mayer RT (1978) Direct fluorometric methods for measuring mixed-function oxidase activity. In: Fleischer S, Packer L (eds) Methods in Enzymology. Academic Press, New York, 52C:372–377
Rivière JL, Bach J (1979) Aldrin epoxidase in liver and small intestine of rat and Japanese quail. Bull Environ Contam Toxicol 21:498–501
Rivière JL (1980) 7-Ethoxycoumarin dealkylase and cytochrome P-450 from grey partridge (Perdix perdix) hepatic and duodenal microsomes. Biochem Biophys Res Commun 97:546–552
Rivière JL, Bach J (1982) Induction of drug-metabolizing enzymes in hepatic and duodenal microsomes from Japanese quail. 8th European Workshop on Drug Metabolism, Liège, 5th–9th September, abstract n∘ 87
Rivière JL (1983) Prochloraz, a potent inducer of the microsomal cytochrome P-450 system. Pestic Biochem Physiol 19:44–52
Rivière JL, Leroux P, Bach J, Gredt M (1984) Effect of some ergosterol biosynthesis inhibiting fungicides on sterols and cytochrome P-450 from the Japanese quailCoturnix coturnix. Pestic Sci 15:317–323
Schafer EW (1972) The acute oral toxicity of 369 pesticidal, pharmaceutical and other chemicals to wild birds. Toxicol Appl Pharmacol 21:315–330
Schafer EW, Bowles WA, Hurlbut J (1983) The acute oral toxicity, repellency and hazard potential of 998 chemicals to one or more species of wild and domestic birds. Arch Environ Contam Toxicol 12:355–382
Schwinn FJ (1983) Ergosterol biosynthesis inhibitors. An overview of their history and contribution to medicine and agriculture. Pestic Sci 15:40–47
Sell JL, Davison KL (1973) Changes in the activities of hepatic microsomal enzymes caused by DDT and dieldrin. Fed Proc 32:2003–2009
Snyder R, Remmer H (1979) Classes of hepatic microsomal mixed-function oxidase inducers. Pharamacol Ther 7:203–244
Stanley PI, Bunyan PJ, Rees WD, Swindon DM, Westlake GE (1978) Pesticide-induced changes in hepatic microsomal enzyme systems: further studies on the effects of 1,1-di(p-chlorophenyl)-2-chloroethylene (DDMU) in the Japanese quail. Chem-Biol Interact 21:203–213
Triolo AJ, Coon JM (1966) The protective effect of aldrin against the toxicity of organophosphate anticholinesterases. J Pharmacol Exp Ther 154:613–623
Walker CH (1980) Species variations in some hepatic microsomal enzymes that metabolize xenobiotics. In: Bridges, JW, Chasseaud LF (eds) Progress in drug metabolism. John Wiley, New York, 5:113–164
Walker CH (1983) Pesticides and birds—Mechanisms of selective toxicity. Agr Environ 9:211–226
Welch RM, Coon JM (1964) Studies on the effects of chlorcyclizine and other drugs on the toxicity of several organophosphate anticholinesterases. J Pharmacol Exp Ther 144:192–198
Wilkinson CF, Hetnarski K, Yellin TO (1972) Imidazole derivatives—A new class of microsomal enzyme inhibitors. Biochem Pharmacol 21:3187–3192
Wilkinson CF, Hetnarski K, Cantwell GP, DiCarlo FJ (1974) Structure-activity relationships in the effects of 1-alkylimidazoles on microsomal oxidationin vitro andin vivo. Biochem Pharmacol 23:2377–2386
Wilkinson CF, Hetnarski K, Denison MS, Guengerich FP (1983) Selectivity of 1-phenylimidazole as a ligand for cytochrome P-450 and as inhibitor of microsomal oxidation. Biochem Pharmacol 32:997–1003
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Rivière, J.L., Bach, J. & Grolleau, G. Effects of prochloraz on drug metabolism in the Japanese quail, grey partridge, chicken, and pheasant. Arch. Environ. Contam. Toxicol. 14, 299–306 (1985). https://doi.org/10.1007/BF01055406
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DOI: https://doi.org/10.1007/BF01055406