Conclusions
Elucidation of the pathogenesis and biological significance of MVP in GBMs is essential for developing a rational treatment directed at the abrogation of neovascularization in these neoplasms. The present quantitative study illustrates the striking heterogeneity of the microvasculature in GBMs such that the number of vessels in many tumor areas does not exceed that of normal white matter. Thus, many regions of GBMs may not be overtly angiogenesis dependent and may be difficult to treat by anti-angiogenic therapy alone. Even in areas with florid MVP the efficacy of anti-angiogenic therapy is questionable since the contribution of these aberrant blood vessels to the functional circulation and thus to the viability and growth of GBMs is unclear.
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References
Folkman J, Klagsbrun M: Angiogenic factors. Science 235: 442–447, 1987
Brem S, Cotran R, Folkman J: Tumor angiogenesis: A quantitative method for histologic grading. J Natl Cancer Inst 48: 347–356, 1972
Wesseling P, Laak JAWM van der, Leeuw H de, Ruiter DJ, Burger PC: Quantitative immunohistological analysis of the microvasculature in untreated human glioblastoma multiforme; Computer-assisted image analysis of whole tumor sections. J Neurosurg 1994, in press
Plate KH, Breier G, Risau W: Molecular mechanisms of developmental and tumor angiogenesis. Brain Pathol 4: 207–218, 1994
Wesseling P, Vandersteenhoven JJ, Downey BT, Ruiter DJ, Burger PC: Cellular components of microvascular proliferation in human glial and metastatic brain neoplasms: A light microscopic and immunohistochemical study of formalin-fixed routinely processed material. Acta Neuropathol 85: 508–514, 1993
Pilkington GJ: Tumour cell migration in the central nervous system. Brain Pathol 4: 157–166, 1994
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This presentation is based on a study that will be published in the Journal of Neurosurgery (see ref. 3) and that was in part financially supported by the University Hospital Nijmegen and the Dutch Cancer Society.
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Wesseling, P., van der Laak, J.A., de Leeuw, H. et al. Computer-assisted analysis of the microvasculature in untreated glioblastomas. J Neuro-Oncol 24, 83–85 (1995). https://doi.org/10.1007/BF01052663
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DOI: https://doi.org/10.1007/BF01052663