Abstract
Experiments using intracellular recording of potentials from neurons of the primary auditory cortex of cats anesthetized with pentobarbital showed that under the influence of tones of characteristic frequency for the neuron under test, or of electrical stimulation of nerve fibers of the spiral ganglion, innervating the center of the receptive field of the neuron, transient excitation of the latter is followed by the development of prolonged (20–250 msec) inhibition. The cause of this inhibition is an IPSP arising in the neuron after the action potential. On the basis of data showing a close connection between inhibition and the preceding spike it is concluded that it arises through the participation of a mechanism of recurrent inhibition. During the action of tones of uncharacteristic frequency or electrical stimulation of the peripheral part of the receptive field of the neuron, a response consisting of EPSP-IPSP arises in the neuron. This IPSP is accompanied by inhibition of spontaneous activity of the neuron and its responses to testing stimulation. It has been shown that this inhibition is lateral in its genesis. Characteristics of these two types of inhibition are given.
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Literature cited
I. A. Vartanyan, "Excitatory and inhibitory frequency zones of responses of the inferior colliculi," Neirofiziologiya,3, No. 4, 369 (1971).
I. O. Volkov, "Responses of auditory cortical neurons in cats to electrical stimulation of nerve fibers innervating receptor cells of different parts of the organ of Corti in the cochlea," Neirofiziologiya,14, No. 4, 418 (1982).
I. O. Volkov and I. O. Dembnovetskii, "Cochleotopic organization of the primary auditory cortex of the cat brain," Neirofiziologiya,11, No. 2, 117 (1979).
V. Mountcastle, "Some functional properties of the somatic afferent system," in: Theory of Communication in Sensory Systems [Russian translation], Mir, Moscow (1964), pp. 185–213.
F. N. Serkov, Electrophysiology of Higher Levels of the Auditory System [in Russian], Naukova Dumka, Kiev (1977).
F. N. Serkov and I. O. Volkov, "Responses of auditory cortical neurons to tones of different frequencies and to electrical stimulation of corresponding parts of the cochlea," Neirofiziologiya,15, No. 5, 527 (1983).
F. N. Serkov and I. O. Volkov, "Intracellular responses of neurons of the primary auditory cortex to tones of different frequencies and electrical stimulation of nerve fibers of the spiral ganglion," Neirofiziologiya,16, No. 1, 123 (1984).
F. N. Serkov and E. Sh. Yanovskii, "Postsynaptic potentials of auditory cortical neurons in cats," Neirofiziologiya,3, No. 4, 339 (1971).
F. N. Serkov and E. Sh. Yanovskii, "Responses of auditory cortical neurons to stimulation of geniculocortical fibers," Neirofiziologiya,4, No. 3, 227 (1972).
F. N. Serkov, E. Sh. Yanovskii, and A. N. Tal'nov, "Effect of pentobarbital, chloralose, and urethane on inhibitory postsynaptic potentials of cortical neurons," Neirofiziologiya,6, No. 4, 339 (1974).
B. I. Fomovskii, "Responses of primary somatosensory cortical neurons to stimulation of different vibrissae in cats," Neirofiziologiya,12, No. 2, 124 (1980).
B. I. Fomovskii, "Responses of primary somatosensory cortical neurons to paired stimulation of the infraorbital nerve and vibrissae in cats," Neirofiziologiya,13, No. 2, 117 (1981).
M. Abeles and M. Goldstein, "Response of single units in the primary auditory cortex of the cat to tones and to tone pairs," Brain Res.,42, No. 2, 337 (1972).
L. M. Aitkin and C. W. Dunlop, "Interplay of excitation and inhibition in the cat medial geniculate body," J. Neurophysiol.,31, No. 1, 44 (1968).
L. M. Aitkin and C. W. Dunlop, "Inhibition in the medial geniculate body of the cat," Exp. Brain Res.,7, No. 1, 68 (1969).
O. D. Creutzfeldt, "Generality of the functional structure of the neocortex," Naturwissenschaften,64, No. 4, 507 (1977).
E. P. Gardner and R. M. Costanzo, "Spatial interaction of multiple-point stimuli in primary somatosensory cortical receptive fields of alert monkeys," J. Neurophysiol.,43, No. 2, 420 (1980).
E. P. Gardner and R. M. Costanzo, "Spatial interaction of multiple-point stimuli in primary somatosensory cortical receptive fields of alert monkeys," J. Neurophysiol.,43, No. 2, 444 (1980).
D. D. Greenwood and N. Maruyama, "Excitatory and inhibitory response areas of auditory neurons in the cochlear nucleus," J. Neurophysiol.,28, No. 4, 863 (1965).
F. C. Helweg, W. Schultz, and O. D. Creutzfeldt, "Extracellular and intracellular recordings from cat's cortical whisker projection area: thalamocortical response transformation," J. Neurophysiol.,40, No. 3, 463 (1977).
D. N. Hubel and T. N. Wiesel, "Receptive fields of single neurons in the cat's striate cortex," J. Physiol. (London),148, No. 3, 574 (1959).
G. Iwamura and S. Inubushi, "Regional diversity in excitatory receptive field organization of cat thalamic ventrobasal neurons," J. Neurophysiol.,37, No. 5, 910 (1974).
G. Iwamura and S. Inubushi, "Functional organization of receptive fields in thalamic ventrobasal neurons examined by neuronal response to iterative electrical stimulation of skin," J. Neurophysiol.,37, No. 5, 920 (1974).
W. Janig, W. A. Spenser, and S. Y. Younkin, "Spatial and temporal features of afferent inhibition of thalamocortical relay cells," J. Neurophysiol.,49, No. 6, 1450 (1979).
S. E. Laskin and W. A. Spenser, "Cutaneous masking. 2. Geometry of excitatory and inhibitory receptive fields of single units in the somatosensory cortex of the cat," J. Neurophysiol.,49, No. 5, 1061 (1979).
W. B. Mountcastle and T. P. S. Powell, "Neural mechanisms subserving cutaneous sensibility, with special reference to the role of afferent inhibition in sensory perception and discrimination," Bull. Johns Hopkins Hosp.,105, No. 4, 201 (1959).
F. Ribaupierre, M. Goldstein, and G. Komshjan, "Intracellular study of the cat's primary auditory cortex," Brain Res.,48, No. 1, 185 (1972).
F. Ribaupierre, M. Goldstein, and G. Komshjan, "Cortical coding of repetitive acoustic pulser," Brain Res.,48, No. 1, 205 (1972).
Additional information
A. A. Bogomolets Institute of Physiology, Academy of Sciences of the Ukrainian SSR, Kiev. Translated from Neirofiziologiya, Vol. 16, No. 2, pp. 194–201, March–April, 1984.
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Serkov, F.N., Volkov, I.O. Characteristics of poststimulus and lateral inhibition in neurons of cat primary auditory cortex. Neurophysiology 16, 160–166 (1984). https://doi.org/10.1007/BF01052308
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DOI: https://doi.org/10.1007/BF01052308