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Dynamics of changes in somatosensory input to the motor cortex following lesion of somatosensory cortical areas in dogs

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Abstract

The pattern of change produced in somatosensory evoked potential (EP) in the forelimb projection area within the motor cortex (MI) following lesion of the projection area of the same limb in the somatosensory cortex (SI) or in parietal cortex area 5 was investigated during chronic experiments on waking dogs. Amplitude of the initial positive — negative wave of EP declined to 28–63% of preoperational level in all cases. No significant recovery of EP was noted for three weeks. Thus, a correlation between change in EP and spontaneous recuperation of the precision motor response occurring within two weeks after lesion of the SI did not exist. Nor was EP reinstated in the MI after ablation of area 5, despite complete but gradual reinstatement of EP (after an initial decline to 53%) in the nearby SI region. This protracted depression of EP seems to have been associated with breakdown of somatotopic sensory input from the SI or from area 5 to the MI, since EP in the motor cortex of the intact hemisphere and the hindlimb projection area within the MI on the lesioned side either remained unchanged or recovered within a week or two.

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Authors
  1. A. G. Frolov
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  2. M. E. Varga
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  3. O. G. Pavlova
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  4. V. N. Mats
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Additional information

Institute of Higher Nervous Activity and Neurophysiology, Academy of Sciences of the USSR, Moscow. Translated from Neirofiziologiya, Vol. 22, No. 1, pp. 61–68, January–February, 1990.

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Frolov, A.G., Varga, M.E., Pavlova, O.G. et al. Dynamics of changes in somatosensory input to the motor cortex following lesion of somatosensory cortical areas in dogs. Neurophysiology 22, 51–57 (1990). https://doi.org/10.1007/BF01052054

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  • DOI: https://doi.org/10.1007/BF01052054

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