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as-Triazin-Derivate, die möglicherweise therapeutische Wirkung besitzen, 15. Mitt.: Synthese von neuen “blockierten 5-substituierten 4-thio-6-azauridinen”

as-triazine derivatives with potential therapeutic action, XV. Synthesis of new “Blocked 5-substituted 4-thio-6-azauridines”

  • Anorganische, Struktur- und Physikalische Chemie
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Abstract

“5-Substituted 4-thio-6-azauracils” [I, 6-alkylthio-3,4-dihydro-5-thioxo-1,2,4-triazin-3(2H)-ones] have been converted with hexamethyldisilazane in 3-trimethylsilyloxy-5-trimethylsilylthio-derivatives(II). These were condensed with 1-O-acetyl-2,3,5-tri-O-benzoyl-d-ribofuranose in the presence of anhydrous stannic chloride to afford the corresponding “1-(2′,3′,5′-tri-O-benzoyl-β-d-ribofuranosyl)-4-thioxo-5-substituted-6-azauracil” (III).

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Authors and Affiliations

  1. Chemisch-Pharmazeutisches Forschungsinstitut, 112 Vitanstr, Bukarest 4, Rumänien

    Carol Cristescu

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  1. Carol Cristescu
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Cristescu, C. as-Triazin-Derivate, die möglicherweise therapeutische Wirkung besitzen, 15. Mitt.: Synthese von neuen “blockierten 5-substituierten 4-thio-6-azauridinen”. Monatshefte für Chemie 108, 1455–1459 (1977). https://doi.org/10.1007/BF01046460

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  • DOI: https://doi.org/10.1007/BF01046460

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