Abstract
Restriction endonuclease fragment length variations (RFLV) on mouse chromosome 10 were detected in four genes, namely, theMyb protooncogene (Myb) and the genes for S100β protein (S100b), phenylalanine hydroxylase (Pah), and interferon-γ (Ifg). RFLV were found in restriction patterns generated withBamHI forMyb, in those generated withBglII forS100b, in those generated withEcoRV forPah, and in those generated withTaqI forIfg. A multipoint backcross was carried out by the mating (129/Sv-Sl/+ × MOL-MIT)F1 × 129/SvJ-+/+. TheSl mutation has phenotypic effects which include deficiencies in pigment cells, germ cells, and blood cells. The following order of genes was derived from the results of the multipoint backcross, with distances between genes in parentheses: centromere—Myb—(34.9 cM)—S100b—(8.5 cM)—Pah—(8.5 cM)—Sl—(12.3 cM)—Ifg—telomere. Most laboratory strains and two strains ofMus musculus domesticus of wild origin carry theMyb a, S100a, Paha, andIfg a alleles. In contrast, a strain ofM. m. musculus, two strains ofM. m. yamashinai, and two strains ofM. m. molossinus carry theMyb b, S100b, Pahb, andIfg b alleles. Other strains of wild origin carry various combinations of these alleles.
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Copeland, N. G., Gilbert, D. J., Cho, B. C., Donovan, P. J., Jenkins, N. A., Cosman, D., Anderson, D., Lyman, S. D., and Williams, D. E. (1990). Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a number of steel alleles.Cell 63175.
Cornall, R. J., Aitman, T. J., Hearne, C. M., and Todd, J. A. (1991). The generation of a library of PCR-analyzed microsatellite variants for genetic mapping of the mouse genome.Genomics 10874.
Gray, P. W., and Goeddel, D. V. (1983). Cloning and expression of murine immune interferon cDNA.Proc. Natl. Acad. Sci. USA 805847.
Hillyard, A. L., Doolittle, D. P., Davisson, M. T., and Roderick, T. H. (1991). Locus map of mouse.Mouse Genome 8916.
Justice, M. J., Siracusa, L. D., Gilbert, D. J., Heisterkamp, N., Groffen, J., Chada, K., Silan, C. M., Copeland, N. G., and Jenkins, N. A. (1990). A genetic linkage map of mouse chromosome 10: Localization of eighteen molecular markers using a single interspecific backcross.Cenetics 125855.
Klempnauer, K., Gonda, T. J., and Bishop, J. M. (1982). Nucleotide sequence of the retroviral leukemia genev-myb and its cellular progenitorc-myb: The architecture of a transduced oncogene.Cell 31453.
Kozak, C. A., Peyser, M., Krall, M., Mariano, T. M., Kumar, C. S., Pestka, S., and Mock, B. A. (1990). Molecular genetic markers spaning mouse chromosome 10.Genomics 8519.
Kuwano, R., Usui, H., Maeda, T., Fukui, T., Yamanari, N., Ohtsuka, E., Ikehara, M., and Takahashi, Y. (1984). Molecular cloning and the complete nucleotide sequence of DNA to mRNA for S-100 protein of rat brain.Nucl. Acid. Res. 127455.
Ledley, F. D., Ledbetter, S. A., Ledbetter, D. H., and Woo, S. L. C. (1988). Localization of mouse phenylalanine hydroxylase locus on chromosome 10.Cytogenet. Cell Genet. 47125.
Ledley, F. D., Grenett, H. E., Dunbar, B. S., and Woo, S. L. C. (1990). Mouse phenylalanine hydroxylase.Biochem. J. 267399.
Love, J. M., Knight, A. M., McAleer, M. A., and Todd, J. A. (1990). Towards construction of a high resolution map of the mouse genome using PCR analysed microsatellites.Nucl. Acids Res. 184123.
Lyon, M. F., and Kirby, M. C. (1991). Mouse chromosome atlas.Mouse Genome 8937.
Sakai, Y., Miyawaki, S., Shimizu, A., Ohno, K., Masaki, S., and Watanabe, T. (1991). A molecular genetic linkage map of mouse chromosome 18 includingSpm, Grl-1, Fim-2/c-fms, andMbp genes, prepared from data obtained by interspecific backcross and restriction fragment length variations.Biochem. Genet. 29103.
Southern, E. M. (1975). Detection of specific sequences among DNA fragments separated by gel electrophoresis.J. Mol. Biol. 98503.
Taylor, B. A., Justice, M. J., and Reeves, R. (1991). Mouse chromosome 10.Mammalian Genome 1S146.
Watanabe, T., Masaki, S., Takahashi, N., Nishimura, M., and Kato, H. (1988). Restriction fragment length polymorphism and chromosome mapping of a mouse homeo box gene,Hox-2.1.Biochem. Genet. 26805.
Watanabe, T., Ohno, K., Shimizu, A., Sakai, Y., Takahashi, M., and Takahashi, N. (1990). Mapping of theHox-3.1 andMyc-1.2 genes on chromosome 15 of the mouse by restriction fragment length variations.Biochem. Genet. 28257.
Watanabe, T., Sakai, Y., Miyawaki, S., Shimizu, A., Koiwai, O., and Ohno, K. (1991). A molecular genetic linkage map of mouse chromosome 19, including thelpr, Ly-44, andTdt genes.Biochem. Genet. 29325.
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Shimizu, A., Sakai, Y., Ohno, K. et al. A molecular genetic linkage map of mouse chromosome 10, including theMyb, S100b, Pah, Sl, andIfg genes. Biochem Genet 30, 529–535 (1992). https://doi.org/10.1007/BF01037591
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DOI: https://doi.org/10.1007/BF01037591