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Sulfonamide release from cellulose acetate membranes

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Summary

Cellulose acetate membranes were chemically modified by esterification with oxalyl chloride which was used as a hydrolytically labile spacer. Then five sulfonamides were attached to the acyl chloride present on the halfesterified membranes to give drug-polymer conjugates. The rate of the hydrolytic cleavage of the spacer-drug linkage was measured in simulated gastric fluids at 37°±0.5°C by determining the amount of drug released by spectrophotometric analysis. The results showed that in all cases the process followed a zero-order kinetics.

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Authors and Affiliations

  1. Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Sucursal 16, Casilla de Correos 61, 5016, Córdoba, Argentina

    P. M. Castellano, M. M. Bonvin, M. M. de Bertorello & M. C. Briñón

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  1. P. M. Castellano
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  2. M. M. Bonvin
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  3. M. M. de Bertorello
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  4. M. C. Briñón
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Castellano, P.M., Bonvin, M.M., de Bertorello, M.M. et al. Sulfonamide release from cellulose acetate membranes. Polymer Bulletin 26, 529–534 (1991). https://doi.org/10.1007/BF01032678

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