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Recovery of penicillin G from fermentation broth with reactive extraction in a mixer-settler

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Summary

In a laboratory countercurrent mixer-settler, penicillin was recovered from its fermentation broth by extraction with Amberlite LA-2 in n-butylacetate at pH 5.0 and reextracted from the ion-pair complex containing a solvent phase with a buffer at 7.2–7.5 with an overall degree of extraction above 90 %.

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Abbreviations

A:

amine

AHP:

complex

c:

concentration

C:

partition coefficent

E:

degree of extraction

HP:

penicillin acid

KG :

equilibrium constant

P, P− :

penicillin acid anion

aq:

aqueous phase

org:

organic phase

A:

amine

AHP:

complex

G:

overall

HP:

free acid

P:

penicillin

References

  • Reschke, M., Schügerl, K. (1984a); Chem. Eng. J.28, B1-B9

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  • Reschke, M., Schügerl, K. (1984c); Chem. Eng. J.29, B25-B29

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  • Reschke, M., Schügerl, K. (1985); Chem. Eng. J31, B19-B26

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  • Reschke, M., Schügerl, K. (1986); Chem. Eng. J.,32, B1-B5

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Author information

Authors and Affiliations

  1. Ges. für Biotechnologische Forschung mbH, Mascheroder Weg 1, D-3300, Braunschweig

    Z. Likidis

  2. Institut für Technische Chemie, Universität Hannover, Callinstr. 3, D-3000, Hannover

    K. Schügerl

Authors
  1. Z. Likidis
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  2. K. Schügerl
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Likidis, Z., Schügerl, K. Recovery of penicillin G from fermentation broth with reactive extraction in a mixer-settler. Biotechnol Lett 9, 229–232 (1987). https://doi.org/10.1007/BF01027154

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  • DOI: https://doi.org/10.1007/BF01027154

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