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Inhibitors of the cleavage of aclacinomycins

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Summary

The reductive cleavage of the aclacinomycins A (I), Y (II), and B (III) by intact mycelia or subcellular fractions of the producer strain S. spec. AM 33352/F43 is suppressed in the presence of uncouplers, complex-forming agents, detergents, and some metal anions such as chromate. Increased concentration of the latter in complete cultures caused rearrangement of I to III.

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Authors and Affiliations

  1. Central Institute of Microbiology and Experimental Therapy, GDR Academy of Sciences, P.O. Box 73, DDR-6900, Jena, GDR

    U. Gräfe, K. Dornberger, W. F. Fleck & G. Schumann

Authors
  1. U. Gräfe
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  2. K. Dornberger
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  3. W. F. Fleck
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  4. G. Schumann
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Gräfe, U., Dornberger, K., Fleck, W.F. et al. Inhibitors of the cleavage of aclacinomycins. Biotechnol Lett 9, 837–842 (1987). https://doi.org/10.1007/BF01026192

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  • DOI: https://doi.org/10.1007/BF01026192

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