Abstract
Prediction of the tertiary structure of a 34 residue N-terminal fragment of parathyroid-hormone-related protein was carried out by the island model. This peptide is known as a major causative agent of humoral hypercalcemia of malignancy, but structural information studied by X-ray diffraction has not been reported. We adopted the secondary structure determined by NMR and packed on the basis of island model of protein folding developed by us. Predicted structure is discussed in connection with the interaction of active sites.
Similar content being viewed by others
References
Barden, J. A., and Kemp, B. E. (1989).Eur. J. Biochem. 184, 379–394.
Blundell, T. L.,et al. (1987).Nature 326, 347–352.
Bremermann, H. A. (1970).Math. Biosci. 9, 1–15.
Chorev, M.,et al. (1990).Biochemistry 29, 1580–1586.
Chou, P. Y., and Fasman, G. D. (1978).Adv. Enzymol. 47, 45–148.
Cohen, F. E., and Kunts, I. D. (1989). InPrediction of Protein Structure and the Principles of Protein Conformation, Plenum, New York, pp. 647–706.
Fenton, A. J.,et al. (1991).Endocrinology 129, 1762–1768.
Fruömmel, C., and Sander, C. (1989).Proteins: Struct. Funct. Genet. 5, 22–37.
Horiuchi, N.,et al. (1987).Science 238, 1566–1568.
Kemp, B. E.,et al. (1987).Science 238, 1568–1570.
Kobayashi, Y.,et al. (1992).Biophys. Chem. 44, 113–127.
Levitt, M., and Warshel, A. (1975).Nature 253, 694–698.
Morikami, K.,et al. (1992).Computers Chem. 16, 243–248.
Moseley, J. M.,et al. (1987).Proc. Natl. Acad. Sci. USA 84, 5048–5052.
Nagasaki, K.,et al. (1989).Biochem. Biophys. Res. Commun. 158, 1036–1042.
Némethy, G., and Scheraga, H. A. (1977).Q. Rev. Biophys. 10, 239–352.
Nutt, R. F.,et al. (1990).Endocrinology 127, 491–493.
Qian, N., and Sejnowski, T. J. (1988).J. Mol. Biol. 202, 865–884.
Saitô, N. (1982).Mem. Sch. Sci. Eng. Waseda Univ. 46, 295–337.
Saitô, N. (1987).Cell Biophys. 11, 321–329.
Saitô, N. (1989). InAdv. Biophys. (Kotani, M., ed.), Vol. 25, Japan Scientific Societies Press, Tokyo, and Elsevier, Amsterdam, pp. 95–132.
Saitô, N.,et al. (1988).Proteins: Struct. Funct. Genet. 3, 199–207.
Saitô, N.,et al. (1990). InProtein Structural Analysis, Folding and Design (Hatano, M., ed.), Japan Scientific Societies Press, Tokyo, and Elsevier, pp. 19–35.
Stewart, A. F.,et al. (1987).Biochem. Biophys. Res. Commun. 146, 672–678.
Strewler, G. J.,et al. (1983).J. Clin. Invest. 71, 769–774.
Suva, L. J.,et al. (1987).Science 237, 893–896.
Watanabe, K.,et al. (1991).Biophys. Chem. 40, 292–301.
Yoshimura, T.,et al. (1991).Biophys. Chem. 40, 277–291.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ota, M., Saitô, N. Prediction of the tertiary structure of parathyroid-hormone-related protein (residues 1–34) by the island model. J Protein Chem 11, 623–628 (1992). https://doi.org/10.1007/BF01024962
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01024962