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Resolution of racemic carboxylic acids via the lipasecatalyzed irreversible transesterification using vinyl esters; Effects of alcohols as nucleophiles and organic solvents on enantioselectivity

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Summary

The lipase-catalyzed irreversible transesterification procedure using vinyl esters has been applied to the resolution of racemic 2-phenoxypropanoic acids. The enantioselectivity was found to be affected profoundly by both the alcohol as a nucleophile and the organic solvent used.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Konan University, Higashinada-ku, Kobe 658, Japan

    Toshifumi Miyazawa, Sota Kurita, Takashi Yamada & Shigeru Kuwata

  2. Department of Chemistry, College of General Education, Kobe University, Nada-ku, Kobe 657, Japan

    Shinichi Ueji

Authors
  1. Toshifumi Miyazawa
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  2. Sota Kurita
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  3. Shinichi Ueji
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  4. Takashi Yamada
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  5. Shigeru Kuwata
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Miyazawa, T., Kurita, S., Ueji, S. et al. Resolution of racemic carboxylic acids via the lipasecatalyzed irreversible transesterification using vinyl esters; Effects of alcohols as nucleophiles and organic solvents on enantioselectivity. Biotechnol Lett 14, 941–946 (1992). https://doi.org/10.1007/BF01020634

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  • DOI: https://doi.org/10.1007/BF01020634

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