Synopsis
Electron microscopic autoradiography of connective tissue obtained from mice and rabbits previously injected with35SO4 indicated that sulphated proteoglycans are localized on collagen fibrils. Ruthenium Red-positive transverse belts surrounding fibrils near the a-bands were heavily labelled, but fine lateral filaments of Ruthenium Red-positive material were not. These filaments, which interconnect collagen fibrils in a variety of connective tissues may represent linear aggregations of hyaluronic acid, glycoproteins and non-sulphated or long-lived sulphated proteoglycans.
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Myers, D.B. Electron microscopic autoradiography of35SO4-labelled material closely associated with collagen fibrils in mammalian synovium and ear cartilage. Histochem J 8, 191–199 (1976). https://doi.org/10.1007/BF01007168
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DOI: https://doi.org/10.1007/BF01007168