Abstract
The intracerebroventricular administration of angiotensin II in pentobarbital-anesthetized cats produced dose-dependent increases in the arterial blood pressure without significant changes in the heart rate. The ablation of the area postrema significantly reduced, but did not abolish, the pressor effect of angiotensin injected into the cerebral ventricles. It follows, then, that the central pressor effect of angiotensin is dependent on the integrity of the area postrema and that this central site, at least in part, contributes to the pressor action of endogenous angiotensin.
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References
Barnes, K. L., and Ferrario, C. M. (1980). Characterization of the sympatho-facilitative area postrema pathway.Clin. Sci. 59: (Suppl. 6): 255s-257s.
Deuben, R. R., and Buckley, J. P. (1970). Identification of a central site of action of angiotensin II.J. Pharmacol. Exp. Ther. 175: 139–146.
Feldberg, W., and Sherwood, S. l., (1953). A permanent cannula for intraventricular injections in cats.J. Physiol. (London) 120: 3–5P.
Ferrario, C. M., Barnes, K. L., Szilagyi, J. E., and Brosnihan, K. B. (1979). Physiological and pharmacological characterization of the area postrema pressor pathways in the normal dog.Hypertension 1: 235–245.
Haywood, J. R., Fink, G. D., Buggy, J., Phillips, M. I.,and Brody, M. J. (1980). The area postrema plays no role in the pressor action of angiotensin in the rat.Am. J. Physiol. 239: H108-H113.
Joy, M. D., and Lowe, R. D. (1970). Evidence that the area postrema mediates the central cardiovascular response to angiotensin II.Nature 228: 1303–1304.
Scroop, G. C., Katić, F., Joy, M. D., and Lowe, R. D. (1971). Importance of central vasomotor effects in angiotensin-induced hypertension.Br. Med. J. 1: 324–326.
Severs, W. B., Daniels, A. E., Smookler, H. H., Kinnard, W. J., and Buckley, J. P. (1966). Interrelation-ship between angiotensin II and the sympathetic nervous system.J. Pharmacol. Exp. Ther. 153: 530–537.
Severs, W. B., Daniels, A. E., and Buckley, J. P. (1967). On the central hypertensive effect of angiotensin II.Int. J. Neuropharmacol. 6: 199–205.
Smookler, H. H., Severs, W. B., Kinnard, W. J., and Buckley, J. P. (1966). Centrally mediated cardio-vascular effects of angiotensin II.J. Pharmacol. Exp. Ther. 153: 485–494.
Szilagyi, J. E., and Ferrario, C. M. (1980). The role of endogenous opiates in the area postrema pressor pathway.Clin. Sci. 59 (Suppl. 6); 267s-269s.
Ueda, H., Katayama, S., and Kato, R. (1972). Area postrema-angiotensin-sensitive site in brain. In Assaykeen, T. A. (ed.),Control of Renin Secretion, Plenum, New York, pp. 109–116.
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Veljković, S., Jovanović-Mićić, D., Japundžić, N. et al. The area postrema and the hypertensive effect of angiotensin. Metab Brain Dis 4, 61–65 (1989). https://doi.org/10.1007/BF00999495
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DOI: https://doi.org/10.1007/BF00999495