Summary
d- and l-amphetamine were tested for effect on turning of unilaterally striatotomized rats and effect on flexor reflex activity. Their capacity for eliciting hypermotility as well as their biochemical effectsin vivo in mice brains were also investigated. The two isomers had similar effects on flexor reflex activity and bio-chemically they were at low dose levels equipotent in releasing noradrenaline. d-amphetamine was more potent than l-amphetamine in eliciting hypermotility, turning and stereotypies. Some differences were also obtained in their respective biochemical effect on central dopaminergic mechanisms. It is concluded that the difference between d- and l-amphetamine in eliciting hypermotility may be due to their different effect on central dopamine neurons.
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Andén, N.-E.: Effects of amphetamine and some other drugs on central catechol-amine mechanisms. In: Amphetamines and Related Compounds, pp. 447–462. Eds.: E. Costa and S. Garattini. New York: Raven Press 1970.
—, Corrodi, H., Fuxe, K., Hökfelt, T.: Increased impulse flow in bulbospinal nor-adrenaline neurons produced by catecholamine receptor blocking agents. Europ. J. Pharmacol.2, 59–64 (1967a).
—, Dahlström, A., Fuxe, K., Larsson, K.: Functional role of the nigro-neostriatal dopamine neurons. Acta pharmacol. (Kbh.)24, 263–274 (1966b).
—, Jukes, M. G. M., Lundberg, A.: The effect of DOPA on the spinal cord. 2. A pharmacological analyses. Acta physiol. scand.67, 387–397 (1966a).
—, Rubenson, A., Fuxe, K., Hökfelt, T.: Evidence for dopamine receptor stimulation by apomorphine. J. Pharm. Pharmacol.19, 627–629 (1967b).
Bertler, Å., Carlsson, A., Rosengren, E.: A method for the fluorimetric determination of adrenaline and noradrenaline in tissues. Acta physiol. scand.44, 273–292 (1958).
Besson, M. J., Cheramy, A., Glowinski, J.: Effects of some psychotropic drugs on dopamine synthesis in the rat striatum. J. Pharmacol. exp. Ther.177, 196–205 (1971).
Carlsson, A.: Amphetamine and brain catecholamines. In: Amphetamines and Related Compounds, pp. 289–299. Eds.: E. Costa and S. Garattini. New York: Raven Press 1970.
Carlsson, A., Corrodi, H., Fuxe, K., Hökfelt, T.: Effects of some antidepressant drugs on the depletion of intraneuronal brain catecholamine stores caused by 4,α-dimethyl-meta-tyramine. Europ. J. Pharmacol.5, 367–373 (1969).
—, Fuxe, K., Hamberger, B., Lindqvist, M.: Biochemical and histochemical studies on the effects of imipramine-like drugs and (+)-amphetamine on central and peripheral catecholamine neurons. Acta physiol. scand.67, 481–497 (1966).
—, Lindqvist, M.: A method for the determination of normetanephrine in brain. Acta physiol. scand.54, 83–86 (1962a).
— —: In-vivo decarboxylation ofα-methyldopa andα-methyl metatyrosine. Acta physiol. scand.54, 87–94 (1962b).
—, Waldeck, B.: A fluorimetric method for the determination of dopamine (3-hydroxytyramine). Acta. physiol. scand.44, 293–298 (1958).
— —: A method for the fluorimetric determination of 3-methoxytyramine in tissues and the occurence of this amine in brain. Scand. J. clin. Lab. Invest.16, 133–138 (1964).
Carr, L. A., Moore, K. E.: Distribution and metabolism of norepinephrine after its administration into the cerebroventricular system of the cat. Biochem. Pharmacol.18, 1907–1918 (1969).
— —: Effects of amphetamine on the contents of norepinephrine and its metabolites in the effluent of perfused cerebral ventricles of the cat. Biochem. Pharmacol.19, 2361–2374 (1970).
Coyle, J. T., Snyder, S. H.: Catecholamine uptake by synaptosomes in homogenates of rat brain: Stereospecificity in different areas. J. Pharmacol. exp. Ther.170, 221–231 (1969).
Ernst, A. M.: Mode of action of apomorphine and dexamphetamine on gnawing compulsion in rats. Psychopharmacologia (Berl.)10, 316–323 (1967).
Javoy, F., Hamon, M., Glowinski, J.: Disposition of newly synthesized amines in cell bodies and terminals of catecholaminergic neurons (I). Effect of amphetamine and thioproperazine on the metabolism of CA in the caudate nucleus, the substantia nigra and the ventromedial nucleus of the hypothalamus. Europ. J. Pharmacol.10, 178–188 (1970).
Moore, K. E.: Toxicity and catecholamine releasing actions of d- and l-amphetamine in isolated and aggregated mice. J. Pharmacol. exp. Ther.142, 6–12 (1963).
Persson, T.: Drug induced changes in3H-catecholamine accumulation after3H-tyrosine. Acta pharmacol. (Kbh.)28, 378–390 (1970).
Prinzmetal, M., Alles, G. A.: The central nervous system stimulant effects of dextro-amphetamine sulphate. Amer. J. med. Sci.200, 665–673 (1940).
Rech, R. H.: Antagonism of reserpine behavioural depression by d-amphetamine. J. Pharmacol. exp. Ther.146, 369–376 (1964).
Smith, C. B.: Effects of d-amphetamine upon brain amine content and locomotor activity of mice. J. Pharmacol. exp. Ther.147, 96–102 (1965).
Stein, L.: Self-stimulation of the brain and the central stimulant action of amphetamine. Fed. Proc.23, 836–850 (1964).
Sulser, F., Sanders-Bush, E.: Effect of drugs on amines in the CNS. Ann. Rev. Pharmacol.11, 209–230 (1971).
Svensson, T. H.: The effect of inhibition of catecholamine synthesis on dexam-phetamine induced central stimulation. Europ. J. Pharmacol.12, 161–166 (1970). Erratum:13, 139–140 (1970).
—, Thieme, G.: An investigation of a new instrument to measure motor activity of small animals. Psychopharmacologia (Berl.)14, 157–163 (1969).
Taylor, K. M., Snyder, S. H.: Amphetamine: Differentiation by d and l isomers of behaviour involving brain norepinephrine or dopamine. Science168, 1487–1489 (1970).
— —: Differential effects of d- and l-amphetamine on behaviour and on catechol-amine disposition in dopamine and norepinephrine containing neurons of rat brain. Brain Res.28, 295–309 (1971).
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Svensson, T.H. Functional and biochemical effects of d- and l-amphetamine on central catecholamine neurons. Naunyn-Schmiedebergs Arch. Pharmak. 271, 170–180 (1971). https://doi.org/10.1007/BF00998578
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DOI: https://doi.org/10.1007/BF00998578