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Aggressivität der Ratte nach kombinierter Behandlung mit Monoaminoxydase-Inhibitoren und anderen psychotropen Pharmaka, insbesondere Thymoleptica

Aggressiveness of the rat, caused by combined treatment with monoamine oxidase inhibitors and other psychotropic drugs, especially thymoleptics

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Summary

  1. 1.

    The combined treatment of rats with MAO-inhibitors and tricyclic thymoleptics caused a central excitation syndrome with aggressiveness. When given alone, MAO-inhibitors and thymoleptics were inactive in this respect.

  2. 2.

    Only phenelzine, iproniazid, and isocarboxazide elicited aggressiveness when combined with imipramine. Harmaline, pheniprazine, pargyline, and tranylcypromine were inactive.

  3. 3.

    Of seven thymoleptics, only imipramine and amitriptyline caused aggressiveness when given after isocarboxazide. Cocaine was not active. Amphetamine produced aggressiveness after isocarboxazide.

  4. 4.

    Aggressiveness was caused bydl-DOPA with and without MAO inhibition, 5-hydroxytryptophan was inactive. Inhibitors of catecholamine synthesis prevented the aggressiveness.

  5. 5.

    Catecholamines, but not 5-hydroxytryptamine, are supposed to play a part in the mechanism leading to aggressiveness.

  6. 6.

    Central excitation with hyperthermia on one hand, and aggressiveness on the other hand are probably not causally related.

Zusammenfassung

  1. 1.

    Kombinierte Behandlung von Ratten mit MAO-Inhibitoren und tricyclischen Thymoleptica führte zu einem Erregungssyndrom mit Aggressivität. Allein gegeben waren MAO-Hemmer und Thymoleptica in dieser Hinsicht wirkungslos.

  2. 2.

    Die MAO-Inhibitoren waren untereinander nicht austauschbar: Phenelzin, Iproniazid und Isocarboxazid, aber nicht Harmalin, Pheniprazin, Pargylin und Tranylcypromin lösten in Kombination mit Imipramin Aggressivität aus.

  3. 3.

    Von sieben Thymoleptica riefen nur Imipramin und Amitriptylin, kombiniert mit Isocarboxazid, Aggressivität hervor; Cocain war wirkungslos, Amphetamin führte erst nach Isocarboxazid zu Aggressivität.

  4. 4.

    dl-DOPA erzeugte ohne und mit MAO-Hemmung Aggressivität, 5-Hydroxytryptophan war wirkungslos. Inhibitoren der Katecholamin-Synthese hemmten die Entstehung der Aggressivität.

  5. 5.

    Katecholamine und nicht 5-Hydroxytryptamin dürften bei der Entstehung der Aggressivität eine Rolle spielen.

  6. 6.

    Zentrale Erregung mit Hyperthermie einerseits und Aggressivität andererseits stehen wahrscheinlich nicht in kausaler Beziehung.

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  1. Institut für Pharmakologie der Medizinischen Akademie Lübeck, Deutschland

    G. Zetler & U. Otten

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Zetler, G., Otten, U. Aggressivität der Ratte nach kombinierter Behandlung mit Monoaminoxydase-Inhibitoren und anderen psychotropen Pharmaka, insbesondere Thymoleptica. Naunyn-Schmiedebergs Arch. Pharmak. 264, 32–54 (1969). https://doi.org/10.1007/BF00997747

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