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Verteilung und Stoffwechsel von14C-markiertem Tetracain nach intravenöser Injektion beim Meerschweinchen

Distribution and metabolism of14C-tetracaine after intravenous injection in guinea-pig

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Summary

The distribution and metabolism of intravenously injected14C-tetracaine were studied in guinea pigs. Initially, the injected drug accumulated in various organs. An especially high concentration of radioactive material was found in the lungs. Probably, the drug is retained by pulmonary tissue as a kind of depot, owing to unknown haemodynamic current mechanisms. The redistribution takes place rather quickly. 90 min after the injection, a radioactivity level higher than that in the serum was found only in the liver, kidneys and adrenals. The excretion via the bile starts more quickly and is quantitatively more important than that in the urine.

Metabolic degradation of tetracaine in the living organism occurs rapidly. As a result of hydrolysis 4-n-butylaminobenzoic acid and 2-dimethylaminoethanol are formed. Apart from these two compounds other metabolites were found in the blood 90 min after the application of the drug.

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Authors and Affiliations

  1. Hals-Nasen-Ohrenklinik und Institut für Pharmakologie der Universität Kiel, Deutschland

    D. Hansen

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  1. D. Hansen
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Der Deutschen Forschungsgemeinschaft sei für die gewährte Sachbeihilfe gedankt.

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Hansen, D. Verteilung und Stoffwechsel von14C-markiertem Tetracain nach intravenöser Injektion beim Meerschweinchen. Naunyn-Schmiedebergs Arch. Pharmak. 265, 347–358 (1970). https://doi.org/10.1007/BF00997192

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  • DOI: https://doi.org/10.1007/BF00997192

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