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Effects of acute and subacute cocaine administration on the CNS dopaminergic system in Wistar-Kyoto and spontaneously hypertensive rats: II. Dopamine receptors

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Abstract

The characteristics of D-1 and D-2 dopamine receptors after acute and subacute cocaine administration were determined in striata and nuclei accumbens from WKY and SHR. In striata from acutely treated rats, significant increases in D-2 receptor density were observed at 30 min, 2 or 24 h following cocaine injection in both strains without changes in affinities. The density of D-1 receptors was significantly decreased 30 min after the injection in WKY, but not in SHR. In striata from subacutely treated rats, the density of D-1 receptors was significantly increased in 3- and 7-day treated WKY, but not in SHR. The affinities of both binding sites remained unchanged. In nuclei accumbens, the changes in both D-1 and D-2 receptors after cocaine administration were similar to those observed in the striatum. The results suggest that cocaine administration alters dopamine receptor binding characteristics. Furthermore, D-1 and D-2 dopamine receptors appear to be differently regulated.

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References

  1. Dackis, C. A., and M. S. Gold 1985. New concepts in cocaine addition: the dopamine depletion hypothesis. Neurosci. Biochem. Rev. 9:469–477.

    Google Scholar 

  2. Church, W. H., Justice Jr, J. B. and L. D. Byrd. 1987. Extracellular dopamine in rat striatum following uptake inhibition by cocaine, nimifensine and benztropine. Eur. J. Pharmacol. 139:345–348.

    Google Scholar 

  3. Nicolaysen, L. C., Pan, H-T., and J. B. Justice Jr. 1988. Extracellular cocaine and dopamine concentrations are linearly related in rat striatum. Brain Res. 456:317–323.

    Google Scholar 

  4. Arbilla, S., Nowak, J. Z., and S. Z. Langer. 1985. Rapid desensitization of presynaptic dopamine autoreceptors during exposure to exogenous dopamine. Brain Res. 337:11–17.

    Google Scholar 

  5. Chang, G. D., and V. D. Ramirez. 1989. Studies of thein vitro catabolism of exogenous dopamine as infused through a push-pull cannula implanted in the rat caudate nucleus. Brain Res. 481:265–273.

    Google Scholar 

  6. Memo, M., Pradham, S., and I. Hanbauer. 1981. Cocaine-induced supersensitivity of striatal dopamine receptors: role of endogenous calmodulin. Neuropharmacol. 20:1145–1150.

    Google Scholar 

  7. Goeders, N. E., and M. J. Kuhar. 1987. Chronic cocaine administration induces opposite changes in dopamine receptors in the striatum and nucleus accumbens. Alcohol and Drug Res. 7:207–216.

    Google Scholar 

  8. Dwoskin, L. P., Peris, J., Yasuda, R. P., Philpott, K., and N. R. Zahniser. 1988. Repeated cocaine administration results in supersensitivity of striatal D-2 dopamine autoreceptor to pergolide. Life Sci. 42:255–262.

    Google Scholar 

  9. Trulson, M. E., and M. J. Ulissey. 1987. Chronic cocaine ad ministration decreases dopamine synthesis rate and increases [3H]spiroperidol binding in rat brain. Brain Res. Bull. 19:35–38.

    Google Scholar 

  10. Van Den Buuse, M., Versteeg, D. H. G., and W. De Jong. 1986. Brain dopamine systems and hypertension. Pages 343–352.in Nakamura, K. (eds), Brain and Blood pressure control, Excerpta Medica International Congress Series 695, Elsevier, Amsterdam.

    Google Scholar 

  11. Bhargava, H. N. 1984. Effect of cyclo (leucyl-glycine) on [3H]spiroperidol binding in the corpus striatum and hypothalamus of spontaneously hypertensive rats. Eur. J. Pharmacol. 100:109–112.

    Google Scholar 

  12. Chiu, P., Rajakumar, G., Chiu, S., Kwan, C-Y., and R. K. Mishra. 1982. Enhanced [3H]spiroperidol binding in striatum of spontaneously hypertensive rat (SHR). Eur. J. Pharmacol. 82:243–244.

    Google Scholar 

  13. Le Fur, G., Guilloux, F., Kabouche, M., Mitrani, N., Ferris, O., and A. Uzan. 1981. Central dopaminergic neurons during development of genetic and DOCA-salt hypertension in the rat. Dev. Brain Res. 1:153–163.

    Google Scholar 

  14. Le Fur, G., Guilloux, F., and A. Uzan. 1983. Evidence for an increase in [3H]spiperone binding in hypothalamic nuclei during the development of spontaneous hypertension in the rat. Clin. Exp. Hyperten. A5:1537–1542.

    Google Scholar 

  15. Lim, D. K., Ito, Y., Hoskins, B., Rockhold, R. W., and I. K. Ho. 1989. Comparative studies of muscarinic and dopamine receptors in three strains of rat. Eur. J. Pharmacol. 165:279–287.

    Google Scholar 

  16. Watanabe, H. K., Hoskins, B., and I. K. Ho. 1987. Sensitivity difference to hepatotoxicity of cocaine in sponteneously hypertansive and Wistar-Kyoto rats. Alcohol Drug Res. 7:363–370.

    Google Scholar 

  17. Van Den Buuse, M., and W. De Jong. 1989. Differential effects of dopaminergic drugs on open-field behavior of spontenaously hypertensive rats and normotensive Wistar-Kyoto rats. J. Pharmacol. Exp. Ther. 248:1189–1196.

    Google Scholar 

  18. Glowinski, J., and L. L. Iversen. 1966. Regional studies of catecholamines in the rat brain-I. The disposition of3H-norepinephrine,3H-dopamine and3H-DOPA in various regions of the rat. J. Neurochem. 13:655–669.

    Google Scholar 

  19. Palkovits, M., and M. J. Brownstein. 1988. Maps and guide to Microdissection of Rat Brain. Page 96. Elsevier Sci. Publishers Co. New York.

    Google Scholar 

  20. Zukin, S. R., Young, A. E., and S. H. Snyder. 1974. Gamma-aminobutyric acid binding to receptor sites in rat central nerve system. Proc. Natl. Acad. Sci. U.S.A. 71:4802–4807.

    Google Scholar 

  21. Sivam, S. P., Norris, J. C., Lim, D. K., Hoskins, B., and I. K. Ho. 1983. Effects of acute and chronic cholinesterase inhibition with diisopropylfluorophosphate on muscarinic, dopamine and GABA receptors of the rat striatum. 40:1414–1422.

  22. Carboni, E., Memo, M., Tanda, G. L., Carruba, M. O., and P. F. Spano. 1985. Effect of temperature and ionic environment on the specific binding of [3H](−)sulpiride to membranes from different rat brain reigons. Neurochem. Int. 7:279–284.

    Google Scholar 

  23. Porceddu, M. L., Giorgi, O., Ongini, E., Mele, S., and G. Biggio. 1986.3H-SCH-23390 binding sites in the rat substantis nigra: Evidence for a presynaptic localization and innervation by dopamine. Life Sci. 39:321–328.

    Google Scholar 

  24. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and R. J. Randall. 1951. Protein measurement with Folin phenol reagent. J. Biol. Chem. 193:265–275.

    Google Scholar 

  25. Munson, P. J., and D. Rodbard. 1980. A versatile computerized approch for the characterization of ligand binding systems. Anal. Biochem. 107:220–239.

    Google Scholar 

  26. List, S. J., and P. Seeman. 1981. Resolution of dopamine and serotonin receptors components of [3H]-spiperone binding to rat brain regions. Proc. Natl. Acad. Sci. USA. 78:2620–2624.

    Google Scholar 

  27. Schnellmann, R. G., Waters, S. J., and D. L. Nelson. 1984. [3H]5-hydroxytryptamine binding sites: Species and tissue variation. J. Neurochem. 42:65–70.

    Google Scholar 

  28. Seeman, P., Ulpian, C., Wreggett, K. A., and J. W. Wells. 1984. Dopamine receptor parameters detected by [3H]spiperone depend on tissue concentration: analysis and examples. J. Neurochem. 43:221–235.

    Google Scholar 

  29. Hadfield, M. G., and E. A. Nugent. 1983. Cocaine: comparative effect on dopamine uptake in extrapyramidal and limbic systems. Biochem. Pharmacol. 32:744–746.

    Google Scholar 

  30. Pitts, D. K., and J. Marwah. 1988. Cocaine and central monoaminergic neurotransmission: A review of electrophysiological studies and comparison to amphetamine and antidepressants. Life Sci. 42:949–968.

    Google Scholar 

  31. Parenti, M., Flauto, C., Parti, E., Vescovi, A., and A. Groppetti. 1986. Differential effect of repeated treatment with L-dopa on dopamine D-1 or D-2 receptors. Neuropharmacol. 25:331–334.

    Google Scholar 

  32. Parker, E. M., and L. X. Cubeddu. 1985. Evidence for autoreceptor modulation of endogenous dopamine release from rabbit caudate nucleusin vitro. J. Pharmacol. Exp. Ther. 232:492–500.

    Google Scholar 

  33. Stoof, J. C., and J. Kebabian. 1984. Two dopamine receptors; Biochemistry, physiology and pharmacology. Life Sci. 35:2281–2296.

    Google Scholar 

  34. Fage, D., and B. Scatton. 1986. Opposing effects of D-1 and D-2 dopamine antagonists on acetylcholine levels in the striatum. Eur. J. Pharmacol. 129:359–362.

    Google Scholar 

  35. Quimet, C. C., Miller, P. E., Hemmings, H. C. Walaas, S. I., and P. Greengard. 1984. DARPP-32, a dopamine- and adenosine 3,5-monophosphate regulated phosphoprotein enriched in dopamine-innervated brain regions. J. Neurosci. 4:111–124.

    Google Scholar 

  36. Barnett, J. V., and R. Kuczenski. 1986. Desensitization of rat striatal dopamine-stimulated adenylate cyclase after acute amphetamine administration. J. Pharmacol. Exp. Ther. 237:820–825.

    Google Scholar 

  37. Trulson, M. E., Babb, S., Joe, J. C., and J. D. Raese. 1986. Chronic cocaine administration deplets tyrosine hydroxylase immunoreactivity in the rat brain nigral striatal system: Quantitative light microscopic studies. Exp. Neurol. 94:744–756.

    Google Scholar 

  38. Fuxe, K., Agnat, L. F., Pich, E. M., Meller, E., and M. Goldstein. 1987. Evidence for a fast receptor turnover of D-1 dopamine receptors in various forebrain regions of the rat. Neurosci. Lett. 81:183–187.

    Google Scholar 

  39. Missale, C., Castelletti, L., Govoni, S., Spano, P. F., Trabucchi, M., and I. Hanbauer. 1985. Dopamine uptake is differentially regulated in rat stiratum and nucleus accumbens. J. Neurochem. 45:51–56.

    Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacology and Toxicology, University of Mississippi Medical Center, 39216, Jackson, Mississippi

    D. K. Lim, Z. J. Yu, B. Hoskins, R. W. Rockhold & I. K. Ho

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  2. Z. J. Yu
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Lim, D.K., Yu, Z.J., Hoskins, B. et al. Effects of acute and subacute cocaine administration on the CNS dopaminergic system in Wistar-Kyoto and spontaneously hypertensive rats: II. Dopamine receptors. Neurochem Res 15, 621–627 (1990). https://doi.org/10.1007/BF00973753

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