Skip to main content
SpringerLink
Log in

Cholinergic systems in muscle and brain in vitamin E-deficient rats

  • Original Articles
  • Published:
Neurochemical Research Aims and scope Submit manuscript

Abstract

Rats fed a vitamin E-deficient diet for 7–8 weeks postweaning showed no change in brain weight or the activity in brain of various enzymes involved in neurotransmitter synthesis and metabolism. Body and muscle weights were markedly reduced. Muscle choline acetyltransferase and acetylcholinesterase activities were significantly elevated on a protein basis, but the total amount of choline acetyltransferase/muscle was essentially normal and total acetylcholinesterase activity was slightly reduced. Total carnitine acetyltransferase and butyrylcholinesterase activities were markedly decreased. The results are quite different from those found in hereditary murine muscular dystrophy and suggest a myogenic etiology for the vitamin E-deficiency-induced condition.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Scott, M. L. 1969. Studies on vitamin E and related factors in nutrition and metabolism. Pages 355–374,in Deluca, H. F. and Suttie, J. W. (eds.), The Fat-Soluble Vitamins, University of Wisconsin Press, Madison.

    Google Scholar 

  2. Goettsch, M., andPappenheimer, A. M. 1931. Nutritional muscular dystrophy in the guinea pig and rabbit. J. Exp. Med. 54:145–165.

    Google Scholar 

  3. Sung, S. C. 1978. Choline acetyltransferase and acetylcholinesterase in muscular dystrophic mice. Muscle Nerve 1:157–161.

    Google Scholar 

  4. Sung, S. C. 1978. Choline acetyltransferase and acetylcholinesterase in dystrophic muscle. Trans. Am. Soc. Neurochem. 9:143.

    Google Scholar 

  5. Singh, V. K., andMcGeer, P. L. 1977. Studies on choline acetyltransferase isolated from human brain. Neurochem. Res. 2:281–291.

    Google Scholar 

  6. Schrier, B. K., Wilson, S. H., andNirenberg, M. 1974. Cultured cell systems and methods for neurobiology. Methods Enzymol. 32:765–788.

    Google Scholar 

  7. Schrier, B. K., andShuster, L. 1967. A simplified radiochemical assay for choline acetyltransferase. J. Neurochem. 14:977–985.

    Google Scholar 

  8. McGeer, P. L., andMcGeer, E. G. 1971. Cholinergic enzyme systems in Parkinson's disease. Arch. Neurol. 25:265–268.

    Google Scholar 

  9. McGeer, P. L., andMcGeer, E. G. 1975. Evidence for glutamic acid decarboxylase containing interneurons in the neostriatum. Brain Res. 91:331–335.

    Google Scholar 

  10. McGeer, E. G., andMcGeer, P. L. 1973. Pages 69–89,in Mandell, A. J. (ed.), New Concepts in Neurotransmitter Regulation, Plenum Press, New York.

    Google Scholar 

  11. Wurtman, R. J., andAxelrod, J. 1963. A sensitive and specific assay for the estimation of monamine oxidase. J. Biochem. Pharmacol. 12:1439–1440.

    Google Scholar 

  12. Lowry, O. H., Rosebrough, N. J., Farr, A. L., andRandall, R. J. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:265–275.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Kinsmen Laboratory of Neurological Research Department of Psychiatry, University of British Columbia, V6T 1W5, Vancouver, B. C., Canada

    S. C. Sung, P. R. Sanberg & E. G. McGeer

Authors
  1. S. C. Sung
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P. R. Sanberg
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. G. McGeer
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sung, S.C., Sanberg, P.R. & McGeer, E.G. Cholinergic systems in muscle and brain in vitamin E-deficient rats. Neurochem Res 3, 815–820 (1978). https://doi.org/10.1007/BF00966003

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00966003

Keywords

Search

Navigation