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PhenylethanolamineN-methyltransferase from the brain and adrenal medulla of the rat

A comparison of their properties

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Abstract

Two different molecular forms of phenylethanolamineN-methyltransferase (PNMT, EC 2.1.1) have been isolated from the brain and adrenal glands of the rat as indicated by certain of their physicochemical properties, such as: molecular weight estimated on the basis of gel chromatography of Sephadex G-100; pH optima; electrophoretic mobility on acrylamide gel; and steady-state kinetic parameters. The highK m value for the brain PNMT has been assumed to be responsible for the low methylation ratio between norepinephrine and epinephrine in the CNS.

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  1. Psychiatric Research Division, University Hospital, S7N OW8, Saskatoon, Saskatchewan, Canada

    Peter H. Yu

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  1. Peter H. Yu
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Yu, P.H. PhenylethanolamineN-methyltransferase from the brain and adrenal medulla of the rat. Neurochem Res 3, 755–762 (1978). https://doi.org/10.1007/BF00965998

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  • DOI: https://doi.org/10.1007/BF00965998

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