Neurochemical Research

, Volume 16, Issue 6, pp 687–692 | Cite as

Reduction of cellular damage induced by cerebral ischemia in rats

  • Albert W. N. Leung
  • Zhixian Mo
  • Youshan Zheng
Original Articles


A model of incomplete cerebral ischemia involving bilateral ligation of the common carotid arteries in rats, was used to examine the potential of a Chinese herbal preparation and of nifedipine to reduce cell damage following cerebral ischemia. The herbal preparation contained ginsengosides and extracts ofPanax notoginseng, Ligusticum chuanxiong Hort.,Carthamus tinctorius L. andSalvia militorrhiza Bge. Histological evidence of cell damage and the formation of peroxidation products were both reduced in rats pretreated with the herbal preparation or with nifedipine. It has been suggested that the free radical reaction is involved in tissue damage, particularly in the pathological neurocyte injury of cerebral ischemia. The results show that in this model of incomplete cerebral ischemia, the degree of lipid peroxidation can be lowered by the pretreatment with Chinese herbs containing ginsengosides or with nifedipine. These drugs maybe beneficial in the treatment of cerebral ischemia in humans.

Key Words

Cerebral ischemia malondialdehyde nifedipine Chinese herbal ginsengosides 


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Copyright information

© Plenum Publishing Corporation 1991

Authors and Affiliations

  • Albert W. N. Leung
    • 1
  • Zhixian Mo
    • 2
  • Youshan Zheng
    • 2
  1. 1.Department of BiochemistryThe Chinese University of Hong KongShatin, N. T.Hong Kong
  2. 2.Department of Chinese MedicineFirst Military Medical CollegeGuangzhouChina

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