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Enantiomerically selective metal complex catalysis. 7. Asymmetric hydrosilylation of imines and oximes on the catalyst [Rh(COD)Cl]2/(S)-phephos

  • Organic Chemistry
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Bulletin of the Academy of Sciences of the USSR, Division of chemical science Aims and scope

Abstract

Asymmetric hydrosilylation of acetophenoxime and cyclic and acyclic imines (with subsequent hydrolysis to amines) was investigated using as catalyst a rhodium complex with the chiral phosphinamino ligand (S)-Phephos. With this method the chiral analog of the antidepressant Pyrazidol was synthesized with an optical yield of 73%.

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Authors and Affiliations

  1. N. D. Zelinskii Institute of Organic Chemistry, Academy of Sciences of the USSR, Moscow

    E. Yu. Zhorov, V. A. Pavlov, O. A. Fedotova, V. I. Shvedov, É. A. Mistryukov, D. N. Platonov, L. S. Gorshkova & E. I. Klabunovskii

Authors
  1. E. Yu. Zhorov
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  2. V. A. Pavlov
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  3. O. A. Fedotova
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  4. V. I. Shvedov
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  5. É. A. Mistryukov
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  6. D. N. Platonov
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  7. L. S. Gorshkova
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  8. E. I. Klabunovskii
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Additional information

Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 4, pp. 865–868, April, 1991.

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Zhorov, E.Y., Pavlov, V.A., Fedotova, O.A. et al. Enantiomerically selective metal complex catalysis. 7. Asymmetric hydrosilylation of imines and oximes on the catalyst [Rh(COD)Cl]2/(S)-phephos. Russ Chem Bull 40, 763–766 (1991). https://doi.org/10.1007/BF00958569

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  • DOI: https://doi.org/10.1007/BF00958569

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