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Formation of bromo-substituted imidazo[1,2-a]pyridines and their aza and thia analogs when the chichibabin reaction is carried out in dimethyl sulfoxide

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The reactions of bromomethyl ketones with 2-aminopyridine, 2-aminopyrimidine, 2-aminothiazole, and 2-aminobenzothiazole in dimethyl sulfoxide lead to bromo-substituted (with respect to the α position of the imadozole ring) imidazo[1,2-a] pyridines, imidazo[1,2-a]pyrimidines, imidazo[2,1-b]thiazoles, and imidazo[2,1-b]-benzothiazoles.

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Authors and Affiliations

  1. Institute of Organic Synthesis, Academy of Sciences of the Latvian SSR, 226006, Riga

    N. O. Saldabol & O. E. Lando

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  1. N. O. Saldabol
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  2. O. E. Lando
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 258–262, February, 1978.

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Saldabol, N.O., Lando, O.E. Formation of bromo-substituted imidazo[1,2-a]pyridines and their aza and thia analogs when the chichibabin reaction is carried out in dimethyl sulfoxide. Chem Heterocycl Compd 14, 211–215 (1978). https://doi.org/10.1007/BF00945338

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  • DOI: https://doi.org/10.1007/BF00945338

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